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학술저널
저자정보
Saurabh Kedia (Department of Gastroenterology All India Institute of Medical Sciences New Delhi India) Raju Sharma (All India Institute of Medical Sciences) Sudheer Kumar Vuyyuru (All India Institute of Medical Sciences) Deepak Madhu (Department of Gastroenterology All India Institute of Medical Sciences) Pabitra Sahu (All India Institute of Medical Sciences) Bhaskar Kante (All India Institute of Medical Sciences) Prasenjit Das (All India Institute of Medical Sciences) Ankur Goyal (All India Institute of Medical Sciences) Karan Madan (All India Institute of Medical Sciences) Govind Makharia (All India Institute of Medical Sciences) Vineet Ahuja (All India Institute of Medical Sciences)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.20 No.2
발행연도
2022.4
수록면
184 - 191 (8page)
DOI
10.5217/ir.2020.00104

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Background/Aims: Intestinal tuberculosis (ITB) is difficult to diagnose due to poor sensitivity of definitive diagnostic tests. ITB may be associated with concomitant pulmonary tuberculosis (PTB) which may remain undetected on chest X-ray. We assessed the role of contrast enhanced computed tomography (CECT) chest in detecting the prevalence of active PTB, and increasing the diagnostic yield in patients with suspected ITB. Methods: Consecutive treatment naive patients with suspected ITB (n=200) who underwent CECT chest (n=88) and had follow-up duration>1 year were recruited in this retrospective study (February 2016 to October 2018). ITB was diagnosed in the presence of caseating granuloma, positive acid fast stain or culture for Mycobacterium tuberculosis on biopsy, presence of necrotic lymph nodes (LNs) on CT enterography or positive response to anti-tubercular therapy. Evidence of active tuberculosis on CECT-chest was defined as presence of centrilobular nodules with or without consolidation/miliary nodules/thick-walled cavity/enlarged necrotic mediastinal LNs. Results: Sixty-five of eighty-eight patients (mean age, 33.8±12.8 years; 47.7% of females) were finally diagnosed as ITB (4-caseating granuloma on biopsy, 12-necrotic LNs on CT enterography, 1-both, and 48-response to anti-tubercular therapy) and 23 were diagnosed as Crohn’s disease. Findings of active TB on CECT chest with or without necrotic abdominal LNs were demonstrated in 5 and 20 patients, respectively. No patient with Crohn’s disease had necrotic abdominal LNs or active PTB. Addition of CECT chest in the diagnostic algorithm improved the sensitivity of ITB diagnosis from 26.2% to 56.9%. Conclusions: Addition of CECT chest significantly improves the sensitivity for definite diagnosis in a patient with suspected ITB.

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