지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 262 - 270 (9page)
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초록· 키워드
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MicroRNAs (miRNAs) are single-stranded, small RNAs (21?23 nucleotides) that function in gene silencing and translational inhibition via the RNA interference mechanism. Most miRNAs originate from host genomic regions, such as intergenic regions, introns, exons, and transposable elements (TEs). Here, we focused on the palindromic structure of medium reiteration frequencies (MERs), which are similar to precursor miRNAs. Five MER consensus sequences (MER5A1, MER53, MER81, MER91C, and MER117) were matched with paralogous transcripts predicted to be precursor miRNAs in the horse genome (equCab2) and located in either intergenic regions or introns. The MER5A1, MER53, and MER91C sequences obtained from RepeatMasker were matched with the eca-miR-544b, eca-miR-1302, and eca-miR-652 precursor sequences derived from Ensembl transcript database, respectively. Each precursor form was anticipated to yield two mature forms, and we confirmed miRNA expression in six different tissues (cerebrum, cerebellum, lung, spleen, adrenal gland, and duodenum) of one thorough-bred horse. MER5A1-derived miRNAs generally showed significantly higher expression in the lung than in other tissues. MER91C-derived miR-NA-5p also showed significantly higher expression in the duodenum than in other tissues (cerebellum, lung, spleen, and adrenal gland). The MER117-overlapped expressed sequence tag generated polycistronic miRNAs, which showed higher expression in the duo-denum than other tissues. These data indicate that horse MER transposons encode miRNAs that are expressed in several tissues and are thought to have biological functions.
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등록된 정보가 없습니다.
참고문헌 (51)
참고문헌 신청
Ahn, K. / 2013 / The novel MER transposon-derived miRNAs in human genome / Gene 512:422~428
Altuvia, Y. / 2005 / Clustering and conservation patterns of human microRNAs / Nucleic Acids Res 33:2697~2706
Balada, E. / 2010 / Implication of human endogenous retroviruses in the development of autoimmune diseases / Int. Rev. Immunol 29:351~370
Bartel, D. P. / 2009 / MicroRNAs: target recognition and regulatory functions / Cell 136:215~233
Borchert, G. M. / 2011 / Comprehensive analysis of microRNA genomic loci identifies pervasive repetitive-element origins / Mob. Genet. Elements 1:8~17
Altuvia, Y. / 2005 / Clustering and conservation patterns of human microRNAs / Nucleic Acids Res 33:2697~2706
Balada, E. / 2010 / Implication of human endogenous retroviruses in the development of autoimmune diseases / Int. Rev. Immunol 29:351~370
Bartel, D. P. / 2009 / MicroRNAs: target recognition and regulatory functions / Cell 136:215~233
Borchert, G. M. / 2011 / Comprehensive analysis of microRNA genomic loci identifies pervasive repetitive-element origins / Mob. Genet. Elements 1:8~17
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