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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 307 - 313 (7page)
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Caloric restriction (CR) has been shown to extend lifespan and prevent cellular senescence in various species ranging from yeast to humans. Many effects of CR may contribute to extend lifespan. Specifically, CR prevents oxidative damage from reactive oxygen species (ROS) by enhancing mitochondrial function. In this study, we characterized 33 single electron transport chain (ETC) gene-deletion strains to identify CR-induced chronological lifespan (CLS) extension mechanisms. Interestingly, defects in 17 of these 33 ETC gene-deleted strains showed loss of both respiratory function and CR-induced CLS extension. On the contrary, the other 16 respiration-capable mutants showed increased CLS upon CR along with increased mitochondrial membrane potential (MMP) and intracellular adenosine triphosphate (ATP) levels, with decreased mitochondrial superoxide generation. We measured the same parameters in the 17 non-respiratory mutants upon CR. CR sim-ultaneously increased MMP and mitochondrial superoxide generation without altering intra-cellular ATP levels. In conclusion, respiration is essential for CLS extension by CR and is important for balancing MMP, ROS, and ATP levels.
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참고문헌 (23)
참고문헌 신청
Barros, M. H. / 2004 / Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae / J. Biol. Chem 279:49883~49888
Choi, K. M. / 2013 / Characterization of global gene expression during assurance of lifespan extension by caloric restriction in budding yeast / Exp. Gerontol 48:1455~1468
Choi, K. M. / 2015 / Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast / FEBS Lett 589:349~357
Hamanaka, R. B. / 2009 / Mitochondrial reactive oxygen species regulate hypoxic signaling / Curr. Opin. Cell Biol 21:894~899
Harman, D. / 1972 / The biologic clock: the mitochondria? / J. Am. Geriatrics Soc 20:145~147
Choi, K. M. / 2013 / Characterization of global gene expression during assurance of lifespan extension by caloric restriction in budding yeast / Exp. Gerontol 48:1455~1468
Choi, K. M. / 2015 / Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast / FEBS Lett 589:349~357
Hamanaka, R. B. / 2009 / Mitochondrial reactive oxygen species regulate hypoxic signaling / Curr. Opin. Cell Biol 21:894~899
Harman, D. / 1972 / The biologic clock: the mitochondria? / J. Am. Geriatrics Soc 20:145~147
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