지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 632 - 642 (11page)
- DOI
- 10.14348/molcells.2017.0076
이용수
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
The DevSR (DosSR) two-component system, which is a major regulatory system involved in oxygen sensing in mycobacteria, plays an im-portant role in hypoxic induction of many genes in mycobacteria. We demonstrated that overex-pression of the kinase domain of Mycobacterium tuberculosis (Mtb) PknB inhibited transcriptional activity of the DevR response regulator in Mycobacterium smegmatis and that this inhibitory effect was exerted through phosphorylation of DevR on Thr180 within its DNA-binding domain. Moreover, the purified kinase domain of Mtb PknB significantly phosphorylated RegX3, NarL, KdpE, TrcR, DosR, and MtrA response regulators of Mtb that contain the Thr residues corresponding to Thr180 of DevR in their DNA-binding domains, implying that transcriptional activities of these response regulators might also be inhibited when the kinase domain of PknB is overexpressed.
목차
등록된 정보가 없습니다.
참고문헌 (56)
참고문헌 신청
Baer, C. E. / 2014 / Biochemical and spatial coincidence in the provisional Ser/Thr protein kinase interaction network of Mycobacterium tuberculosis / J. Biol. Chem 289:20422~20433
Chao, J. D. / 2010 / Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis / J. Biol. Chem 285:29239~29246
Chawla, Y. / 2014 / Protein kinase B (PknB) of Mycobacterium tuberculosis is essential for growth of the pathogen in vitro as well as for survival within the host / J. Biol. Chem 289:13858~13875
Cho, H. Y. / 2009 / Structural insight into the heme-based redox sensing by DosS from Mycobacterium tuberculosis / J. Biol. Chem 284:13057~13067
Cole, S. T. / 1998 / Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence / Nature 393:537~544
Chao, J. D. / 2010 / Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis / J. Biol. Chem 285:29239~29246
Chawla, Y. / 2014 / Protein kinase B (PknB) of Mycobacterium tuberculosis is essential for growth of the pathogen in vitro as well as for survival within the host / J. Biol. Chem 289:13858~13875
Cho, H. Y. / 2009 / Structural insight into the heme-based redox sensing by DosS from Mycobacterium tuberculosis / J. Biol. Chem 284:13057~13067
Cole, S. T. / 1998 / Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence / Nature 393:537~544
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Signal Convergence between Ser/Thr Protein Kinases and Two-component Systems : Inhibition of the SenX3-RegX3 Two-component System by PknB in Mycobacteria
한국미생물학회 학술대회논문집
2018 .04
-
DNA Repair in Mycobacteria
한국미생물학회 학술대회논문집
2016 .04
-
마이코박테리움을 신속하게 배양할 수 있는 성장 인자에 관한연구
대한임상검사과학회지
2019 .01
-
Mycobacterium tuberculosis MPT63-derived Peptide Regulates Mycobacteria Survival by Innate Immune Response
한국미생물학회 학술대회논문집
2021 .08
-
Skin Infection Caused by Mycobacterium abscessus in a Healthy Adult
대한의진균학회지
2022 .06
-
Expression of Ribosomal Protein Genes under Respiration-inhibitory Conditions in Mycobacterium smegmatis
한국미생물학회 학술대회논문집
2021 .08
-
In Vitro Combination Studies of Respiration Inhibitor against Mycobacterium tuberculosis
한국미생물학회 학술대회논문집
2021 .08
-
Horizontal Gene Transfer in Evolution of Mycobacterium tuberculosis towards Pathogenicity
한국미생물학회 학술대회논문집
2016 .04
-
Inactivation of Mycobacteria by Radicals from Non-Thermal Plasma Je
Journal of Microbiology and Biotechnology
2019 .01
-
Ursolic Acid Reduces Mycobacterium tuberculosis- Induced Nitric Oxide Release in Human Alveolar A549 cells
Molecules and Cells
2015 .07
-
Apoptotic Effect of Macrophages against Mycobacterium tuberculosis
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .12
-
Latest Comprehensive Knowledge of the Crosstalk between TLR Signaling and Mycobacteria and the Antigens Driving the Process
Journal of Microbiology and Biotechnology
2019 .01
-
Immunomodulatory Roles of PE/PPE Proteins and Their Implications in Genomic Features of Mycobacterium tuberculosis
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .09
-
Host Immune Pathways to Mycobacterium tuberculosis Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2024 .09
-
Three Mechanisms of Oxygen Sensing in Mycobacteria : Regulation of Gene Expression in Response to Changes in Oxygen Tensions
한국미생물학회 학술대회논문집
2016 .04
-
최근 10년간 광주 2차병원의 호흡기검체에서 분리된 비결핵항산균의 폐질환 유병률에 대한 연구
대한임상검사과학회지
2020 .01
-
Regulatory Network of Alternative Sigma Factor SigF in Mycobacterium smegmatis
한국미생물학회 학술대회논문집
2019 .04
-
Next Generation Sequencing to Predict Drug Resistance of Mycobacterium tuberculosis Isolates in Korean TB Patients
한국미생물학회 학술대회논문집
2017 .04
-
Identification of the Transcriptional Regulator RamB (MSMEG_0906) Related to the Regulation of the Gene Encoding Isocitrate Lyase in Mycobacterium smegmatis
한국미생물학회 학술대회논문집
2019 .04
-
Suffocating Mycobacteria: New Approaches for the Treatment of Tuberculosis and Other Mycobacterial Diseases
한국미생물학회 학술대회논문집
2018 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0