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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.11
- 수록면
- 805 - 813 (9page)
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The role of phospholipase D (PLD) in cancer development and management has been a major area of interest for researchers. The purpose of this mini-review is to explore PLD and its distinct role during chemotherapy including anti-apoptotic function. PLD is an enzyme that belongs to the phospholipase super family and is found in a broad range of organisms such as viruses, yeast, bacteria, animals, and plants. The function and activity of PLD are widely de-pendent on and regulated by neurotransmitters, hormones, small monomeric GTPases, and lipids. A growing body of research has shown that PLD activity is significantly increased in cancer tissues and cells, indicating that it plays a critical role in signal transduction, cell proliferation, and anti-apoptotic processes. In addition, recent studies show that PLD is a downstream transcriptional target of proteins that contribute to inflammation and carcinogenesis such as Sp1, NFκB, TCF4, ATF-2, NFATc2, and EWS-Fli. Thus, compounds that inhibit expression or activity of PLD in cells can be potentially useful in reducing inflammation and sensitizing resistant cancers during chemotherapy.
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참고문헌 (102)
참고문헌 신청
Alberghina, M. / 2010 / Phospholipase A(2): new lessons from endothelial cells / Microvasc. Res 80:280~285
Ammar, M. R. / 2013 / Lipids in Regulated Exocytosis: What are They Doing? / Front. Endocrinol 4:125
Aoki, J. / 2004 / Mechanisms of lysophosphatidic acid production / Semin. Cell Dev. Biol 15:477~489
Aoki, J. / 2007 / Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family / Biochimie 89:197~204
Baba, T. / 2014 / Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics / J. Biol. Chem 289:11497~11511
Ammar, M. R. / 2013 / Lipids in Regulated Exocytosis: What are They Doing? / Front. Endocrinol 4:125
Aoki, J. / 2004 / Mechanisms of lysophosphatidic acid production / Semin. Cell Dev. Biol 15:477~489
Aoki, J. / 2007 / Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family / Biochimie 89:197~204
Baba, T. / 2014 / Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics / J. Biol. Chem 289:11497~11511
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