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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 168 - 178 (11page)
- DOI
- 10.14348/molcells.2018.0008
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초록· 키워드
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Intracellular communication via ubiquitin (Ub) signaling impacts all aspects of cell biology and regulates pathways critical to human development and viability; therefore aberrations or defects in Ub signaling can contribute to the pathogenesis of human diseases. Ubiquitination consists of the addition of Ub to a substrate protein via coordinated action of E1-activating, E2-conjugating and E3-ligating enzymes. Approximately 40 E2s have been identified in humans, and most are thought to be involved in Ub transfer; although little information is avail-able regarding the majority of them, emerging evidence has highlighted their importance to human health and disease. In this review, we focus on recent insights into the pathogenetic roles of E2s (particularly the ubiquitin-conjugating enzyme E2O [UBE2O]) in debilitating diseases and cancer, and discuss the tantalizing prospect that E2s may someday serve as potential therapeutic targets for human diseases.
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등록된 정보가 없습니다.
참고문헌 (101)
참고문헌 신청
Andersen, P.L. / 2005 / Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A / J. Cell Biol. 170:745~755
Banerjee, S. / 2007 / Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents / Oncogene 26:6509~6517
Barrera, M.J. / 2016 / Pro-inflammatory cytokines enhance ERAD and ATF6alpha pathway activity in salivary glands of Sjogren's syndrome patients / J. Autoimmun. 75:68~81
Bartke, T. / 2004 / Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase / Mol. Cell 14:801~811
Berleth, E.S. / 1996 / Mechanism of ubiquitin conjugating enzyme E2-230K: catalysis involving a thiol relay? / Biochemistry 35:1664~1671
Banerjee, S. / 2007 / Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents / Oncogene 26:6509~6517
Barrera, M.J. / 2016 / Pro-inflammatory cytokines enhance ERAD and ATF6alpha pathway activity in salivary glands of Sjogren's syndrome patients / J. Autoimmun. 75:68~81
Bartke, T. / 2004 / Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase / Mol. Cell 14:801~811
Berleth, E.S. / 1996 / Mechanism of ubiquitin conjugating enzyme E2-230K: catalysis involving a thiol relay? / Biochemistry 35:1664~1671
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