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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 301 - 310 (10page)
- DOI
- 10.14348/molcells.2018.2190
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초록· 키워드
오류제보하기
LysR-type transcriptional regulators (LTTRs) contain an N-terminal DNA binding domain (DBD) and a C-terminal regulatory domain (RD). Typically, LTTRs function as homotetramers. VV2_1132 was identified in Vibrio vulnificus as an LTTR that is a homologue of HypT (also known as YjiE or QseD) in Escherichia coli. In this study, we determined the crystal structure of full-length VV2_1132 at a resolution of 2.2 Å, thereby revealing a novel combination of the domains in the tetrameric assembly. Only one DBD dimer in the tetramer can bind to DNA, because the DNA binding motifs of the other DBD dimer are completely buried in the tetrameric assembly. Structural and functional analyses of VV2_1132 suggest that it might not perform the same role as E. coli HypT, indicating that further study is required to elucidate the function of this gene in V. vulnificus. The unique structure of VV2_1132 extends our knowledge of LTTR function and mechanisms of action.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Adams, P.D. / 2010 / PHENIX: a comprehensive Python-based system for macromolecular structure solution / Acta Crystallogr. D Biol. Crystallogr. 66:213~221
Alanazi, A.M. / 2013 / The DNAbinding domain of BenM reveals the structural basis for the recognition of a T-N11-A sequence motif by LysR-type transcriptional regulators / Acta Crystallogr. D Biol. Crystallogr. 69:1995~2007
Choi, H. / 2001 / Structural basis of the redox switch in the OxyR transcription factor / Cell 105:103~113
Drazic, A. / 2014 / Tetramers are the activation-competent species of the HOCl-specific transcription factor HypT / J. Biol. Chem. 289:977~986
Drazic, A. / 2013 / Methionine oxidation activates a transcription factor in response to oxidative stress / Proc. Natl. Acad. Sci. USA 110:9493~9498
Alanazi, A.M. / 2013 / The DNAbinding domain of BenM reveals the structural basis for the recognition of a T-N11-A sequence motif by LysR-type transcriptional regulators / Acta Crystallogr. D Biol. Crystallogr. 69:1995~2007
Choi, H. / 2001 / Structural basis of the redox switch in the OxyR transcription factor / Cell 105:103~113
Drazic, A. / 2014 / Tetramers are the activation-competent species of the HOCl-specific transcription factor HypT / J. Biol. Chem. 289:977~986
Drazic, A. / 2013 / Methionine oxidation activates a transcription factor in response to oxidative stress / Proc. Natl. Acad. Sci. USA 110:9493~9498
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