지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 637 - 646 (10page)
- DOI
- 10.14348/molcells.2021.0077
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초록· 키워드
오류제보하기
Free fatty acids are converted to acyl-CoA by long-chain acyl-CoA synthetases (ACSLs) before entering into metabolic pathways for lipid biosynthesis or degradation. ACSL family members have highly conserved amino acid sequences except for their N-terminal regions. Several reports have shown that ACSL1, among the ACSLs, is located in mitochondria and mainly leads fatty acids to the β-oxidation pathway in various cell types. In this study, we investigated how ACSL1 was localized in mitochondria and whether ACSL1 overexpression affected fatty acid oxidation (FAO) rates in C2C12 myotubes. We generated an ACSL1 mutant in which the N-terminal 100 amino acids were deleted and compared its localization and function with those of the ACSL1 wild type. We found that ACSL1 adjoined the outer membrane of mitochondria through interaction of its N-terminal region with carnitine palmitoyltransferase-1b (CPT1b) in C2C12 myotubes. In addition, overexpressed ACSL1, but not the ACSL1 mutant, increased FAO, and ameliorated palmitate-induced insulin resistance in C2C12 myotubes. These results suggested that targeting of ACSL1 to mitochondria is essential in increasing FAO in myotubes, which can reduce insulin resistance in obesity and related metabolic disorders.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Badin, P. M. / 2013 / Dynamics of skeletal muscle lipid pools / Trends Endocrinol. Metab 24:607~615
Bowman, T. A. / 2016 / Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption / Mol. Metab 5:210~220
Bruce, C. R. / 2009 / Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance / Diabetes 58:550~558
Bu, S. Y. / 2009 / Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity / J. Biol. Chem 284:30474~30483
Chaurasia, B. / 2015 / Ceramides - lipotoxic inducers of metabolic disorders / Trends Endocrinol. Metab 26:538~550
Bowman, T. A. / 2016 / Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption / Mol. Metab 5:210~220
Bruce, C. R. / 2009 / Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance / Diabetes 58:550~558
Bu, S. Y. / 2009 / Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity / J. Biol. Chem 284:30474~30483
Chaurasia, B. / 2015 / Ceramides - lipotoxic inducers of metabolic disorders / Trends Endocrinol. Metab 26:538~550
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