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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 1,826 - 1,833 (8page)
- DOI
- 10.1016/j.net.2020.01.031
이용수
초록· 키워드
오류제보하기
Administration of stable iodine has been considered a best measure to protect the thyroid from internal irradiation by radioiodine intake, and its efficacy on thyroid protection has been quantitatively evaluated in several simulation studies on the basis of simple iodine biokinetic models (i.e., three-compartment model). However, the new iodine biokinetic model adopted by the International Commission on Radiological Protection interprets and expresses the thyroid blocking phenomenon differently. Therefore, in this study, the new model was analyzed in terms of thyroid blocking and implemented to reassess the protective effects and to produce dosimetric data. The biokinetic model calculation was performed using computation modules developed by authors, and the results were compared with those of experimental data and prior simulation studies. The new model predicted protective effects that were generally consistent with those of experimental data, except for those in the range of stable iodine administration 72 h before radioiodine exposure. Additionally, the dosimetric data calculated in this study demonstrates a critical limitation of the three-compartment model in predicting bioassay functions, and indicated that dose assessment 1 d after exposure would result in a similar dose estimate irrespective of the administration time of stable iodine
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
World Health Organization / 2017 / Iodine Thyroid Blocking: Guidelines for Use in Planning for and Responding to Radiological and Nuclear Emergencies
P. Verger / 2001 / Iodine kinetics and effectiveness of stable iodine prophylaxis after intake of radioactive iodine : a review / Thyroid 11(4):353~360
D. Ramsden / 1967 / Speight, Radioiodine uptakes in the thyroid. Studies of the blocking and subsequent recovery of the gland following the administration of stable iodine / Health Phys 13(6):633~646
R. Wootton / 1978 / A computer simulation study of optimal thyroid radiation protection during investigations involving the administration of radioiodine-labelled pharmaceuticals / Br. J. Radiol 51(604):265~272
M. Jang / 2008 / Age-dependent potassium iodide effect on the thyroid irradiation by 131I and 133I in the nuclear emergency / Radiat. Protect. Dosim 130(4):499~502
P. Verger / 2001 / Iodine kinetics and effectiveness of stable iodine prophylaxis after intake of radioactive iodine : a review / Thyroid 11(4):353~360
D. Ramsden / 1967 / Speight, Radioiodine uptakes in the thyroid. Studies of the blocking and subsequent recovery of the gland following the administration of stable iodine / Health Phys 13(6):633~646
R. Wootton / 1978 / A computer simulation study of optimal thyroid radiation protection during investigations involving the administration of radioiodine-labelled pharmaceuticals / Br. J. Radiol 51(604):265~272
M. Jang / 2008 / Age-dependent potassium iodide effect on the thyroid irradiation by 131I and 133I in the nuclear emergency / Radiat. Protect. Dosim 130(4):499~502
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