지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제48권 제3호
- 발행연도
- 2018.5
- 수록면
- 323 - 332 (10page)
- DOI
- 10.1007/s40005-017-0324-x
이용수
초록· 키워드
오류제보하기
The purpose of this study was to prepare chitosan- dextran sulphate and chitosan-sodium tripolyphosphate nanoparticles of Dorzolamide HCl. Dorzolamide HCl is used in higher doses (2?2.2%) topically resulting topical as well as systemic side effects, reducing the dose and making the formulation stay in ocular cavity can reduce the side effects. In the present study mucoadhesive nanoformulations of Dorzolamide HCl have been prepared by Ionotropic gelation mechanism and characterized for different parameters like particle size, zeta potential, drug entrapment, particle morphology; in-vitro drug release, ex-vivo transcorneal permeation and in vivo efficacy. The particles showed sustained in vitro drug release which followed the Higuchi kinetic model and release the drug by a combination of dissolution and diffusion. The formulations, namely DD3 and DS6, having least particle size (182.63 ± 4.64 and 172.3 ± 9.03 nm) and highest zeta potential (43.03 ± 0.51 and 36.46 ± 0.59 mV) were selected for further studies.
The particles were spherical and scattered. PXRD and DSC indicated decrease in crystallinity of drug in the nanoparticle formulation. Optimized formulations exhibited excellent transcorneal permeation with no signs of corneal damage (% hydration 75?80%) and found mucoadhesive (93.37 ± 1.86% and 91.59 ± 1.48%) and stable. The in vivo ocular hypotensive activity revealed significantly higher hypotensive activity (p < 0.05) with no signs of ocular irritation.
Hence can be considered for the clinical application.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Ameeduzzafar / 2014 / Chitosan nanoparticles amplify the ocular hypotensive effect of cateolol in rabbits / Int J Biol Macromol 65:479~491
Berthold A / 1996 / Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for antiinflammatory drugs / J Control Rel 39:17~25
Bhatta RS / 2012 / Mucoadhesive nanoparticles for prolonged ocular delivery of natamycin: in vitro and pharmacokinetics studies / Int J Pharm 432:105~112
Calvo P / 1997 / Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers / J Appl Polym Sci 63:125~132
Cegnar M / 2004 / Cystatin Incorporated in poly(lactide-co-glycolide) Nanoparticles: development and fundamental studies on preservation of its activity / Eur J Pharm Sci 22:357~364
Berthold A / 1996 / Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for antiinflammatory drugs / J Control Rel 39:17~25
Bhatta RS / 2012 / Mucoadhesive nanoparticles for prolonged ocular delivery of natamycin: in vitro and pharmacokinetics studies / Int J Pharm 432:105~112
Calvo P / 1997 / Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers / J Appl Polym Sci 63:125~132
Cegnar M / 2004 / Cystatin Incorporated in poly(lactide-co-glycolide) Nanoparticles: development and fundamental studies on preservation of its activity / Eur J Pharm Sci 22:357~364
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