지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제51권 제6호
- 발행연도
- 2021.11
- 수록면
- 759 - 766 (8page)
- DOI
- 10.1007/s40005-021-00545-9
이용수
초록· 키워드
오류제보하기
Purpose Rebamipide (RBM) is known to have a specific absorption window in the upper GI tract. However, there have been no in vivo studies reporting the regional absorption of RBM, which may lead to misjudgment in formulation development considering the many other physiological factors involved in oral absorption. Therefore, this study aimed to assess the regional absorption of RBM.
Methods Barium sulfate was incorporated into RBM-sustained release (SR) tablets as a radiopaque marker and the location of RBM-SR tablets was monitored using X-ray imaging after oral administration of RBM-SR tablets in Beagle dogs.
Results Based on the gastric residence time (GRT) of RBM-SR tablets, dogs were divided into two groups: GRT low for 0.25 and 1.5 h and GRT high for 3 and 5 h. GRT high had significantly delayed time to reach peak plasma concentration (Tmax), longer mean residence time (MRT), and higher area under the plasma concentration?time curve from time zero to the last observation time point (AUC last) than GRT low, which indicates the presence of an absorption window in the upper GI tract.
Conclusion This study, for the first time, reports on the regional absorption of RBM. The findings of this study may be useful for developing RBM-SR formulations.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Ha J-M / 2017 / Implementation of quality by design for formulation of rebamipide gastroretentive tablet / AAPS Pharm Sci Tech 18(8):3129~3139
Huang B-B / 2008 / Permeabilities of rebamipide via rat intestinal membranes and its colon specific delivery using chitosan capsule as a carrier / World J Gastroenterol 14(31):4928~4937
Hwang K-M / 2019 / Swellable and porous bilayer tablet for gastroretentive drug delivery: Preparation and in vitro-in vivo evaluation / Int J Pharm 572:118783
Kararli TT / 1995 / Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals / Biopharm Drug Dispos 16(5):351~380
Kim TH / 2018 / Regional absorption of fimasartan in the gastrointestinal tract by an improved in situ absorption method in rats / Pharmaceutics 10(4):174
Huang B-B / 2008 / Permeabilities of rebamipide via rat intestinal membranes and its colon specific delivery using chitosan capsule as a carrier / World J Gastroenterol 14(31):4928~4937
Hwang K-M / 2019 / Swellable and porous bilayer tablet for gastroretentive drug delivery: Preparation and in vitro-in vivo evaluation / Int J Pharm 572:118783
Kararli TT / 1995 / Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals / Biopharm Drug Dispos 16(5):351~380
Kim TH / 2018 / Regional absorption of fimasartan in the gastrointestinal tract by an improved in situ absorption method in rats / Pharmaceutics 10(4):174
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