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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 505 - 512 (8page)
- DOI
- 10.5668/JEHS.2021.47.6.505
이용수
초록· 키워드
오류제보하기
-Background: The occurrence of environmental disease is known to be associated with chronic exposure to toxic chemicals, including waterborne contaminants, air/indoor pollutants, asbestos, ingredients in humidifier disinfectants, etc.
Objectives: In this study, we reviewed toxicological studies related to environmental disease as defined by the Environmental Health Act in Korea and toxic chemicals. We also suggested a direction for future toxicological research necessary for the prevention and management of environmental disease.
Methods: Trends in previous studies related to environmental disease were investigated through PubMed and Web of Science. A detailed review was provided on toxicological studies related to the humidifier disinfectants. We identified adverse outcome pathways (AOPs) that can be linked to the induction of environmental diseases, and proposed a chemical screening system that uses AOP, chemical toxicity big data, and deep learning models to select chemicals that induce environmental disease.
Results: Research on chemical toxicity is increasing every year, but there is a limitation to revealing a clear causal relationship between exposure to chemicals and the occurrence of environmental disease. It is necessary to develop various exposure- and effect-biomarkers related to disease occurrence and to conduct toxicokinetic studies. A novel chemical screening system that uses AOP and chemical toxicity big data could be useful for selecting chemicals that cause environmental diseases.
Conclusions: From a toxicological point of view, developing AOP related to environmental diseases and a deep learning-based chemical screening system will contribute to the prevention of environmental diseases in advance.
목차
등록된 정보가 없습니다.
참고문헌 (52)
참고문헌 신청
Koh SB / 2012 / Environmental diseases / J Korean Med Assoc 55(3):212~213
Korea Ministry of Government Legislation / Environmental Health Act
Prüss-Üstün A / 2006 / Preventing Disease through Healthy Environments: Towards an Estimate of the Environmental Burden of Disease / World Health Organization
National Institute of Environmental Health Sciences / Environmental Diseases from A to Z
Zeliger HI / 2015 / Causes, mechanisms and prevention of environmental diseases / Dual Diagn 1(1):1~18
Korea Ministry of Government Legislation / Environmental Health Act
Prüss-Üstün A / 2006 / Preventing Disease through Healthy Environments: Towards an Estimate of the Environmental Burden of Disease / World Health Organization
National Institute of Environmental Health Sciences / Environmental Diseases from A to Z
Zeliger HI / 2015 / Causes, mechanisms and prevention of environmental diseases / Dual Diagn 1(1):1~18
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