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논문 기본 정보

자료유형
학술저널
저자정보
울지 (동아대학교 의과대학 예방의학교실) 김병권 (동아대학교 의과대학 예방의학교실) 손현진 (동아대학교 의과대학 예방의학교실) 조성식 (동아대학교 의과대학 직업환경의학교실) 김권민 (동아대학교 중금속노출 환경보건센터) 임현주 (동아대학교) 권정연 (동아대학교) 김기환 ((주)젠큐브플러스) 홍영습 (동아대학교)
저널정보
한국환경보건학회 한국환경보건학회지 한국환경보건학회지 제47권 제6호
발행연도
2021.12
수록면
530 - 539 (10page)
DOI
10.5668/JEHS.2021.47.6.530

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Background: In South Korea, areas around abandoned metal mines are designated as regions with high arsenic (As) contamination. However, studies assessing urinary As exposure, As metabolism, and relevant genetic polymorphisms in residents of these metal mine areas are lacking. Objectives: To identify factors associated with As exposure and evaluate the effects of MTHFR, AS3MT, and GSTO1 genetic polymorphisms on As metabolism in residents of abandoned metal mine areas by measuring urinary As species. Methods: Urinary As species (arsenite [As3+], arsenate [As5+], monomethyl arsonic acid, and dimethylarsinic acid) were isolated using high-performance liquid chromatography in combination with?inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Four genetic polymorphisms (MTHFR A222V, MTHFR E429A, GSTO1 A140D, As3MT M287T) were analyzed in 144 residents of four areas around abandoned metal mines. Results: The study sample was comprised of 34.7% men and 65.3% women, with a mean age of 70.7±10.9 years. The urinary inorganic As concentration was higher among those consuming more than half locally produced rice (0.31 μg/L) than those consuming less than half such rice (0.18 μg/L). The urinary dimethylarsinic acid concentration was higher in the group that had consumed seafood in the past day (31.68 μg/L) than in those who had not (22.37 μg/L). Furthermore, individuals heterozygous in the MTHFR A222V and GSTO1 A140D polymorphism had higher urinary arsenic species concentrations than did individuals with a wild type or homozygous for the variant allele. Conclusions: Consumption of locally produced rice was associated with inorganic As exposure, whereas seafood consumption was associated with organic As exposure among residents of abandoned metal mine areas. There was no clear association between MTHFR A222V and GSTO1 A140D polymorphisms and As metabolism.

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