지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 641 - 649 (9page)
- DOI
- https://doi.org/10.4111/icu.20210278
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초록· 키워드
오류제보하기
Purpose: Many studies identified that the preoperative neutrophil-to-lymphocyte ratio (PNLR) was associated with patient prognosis in non-muscle-invasive bladder cancer (NMIBC). We hypothesized that PNLR could be prognostic in patients with histological variants of NMIBC (VH-NMIBC).
Materials and Methods: This retrospective study included patients with VH-NMIBC admitted at our center between January 2009 and May 2019. The best cut-off value of NLR was measured by the receiver operating characteristic curve and Youden index. The Kaplan-Meier method and Cox proportional hazard regression models were employed to evaluate the association between PNLR and disease prognosis, including recurrence-free survival (RFS), progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS).
Results: A total of 243 patients with VH-NMIBC were enrolled in our study. According to the Kaplan-Meier method results, patients with PNLR ≥2.2 were associated with poor RFS (p<0.001), PFS (p<0.001), CSS (p<0.001), and OS (p<0.001). Multivariable analyses indicated that PNLR ≥ 2.2 was an independent prognostic factor of RFS (hazard ratio [HR], 2.11; 95% confidence interval [CI, 1.57?1.83; p<0.001), PFS (HR, 2.34; 95% CI, 1.70?3.21; p<0.001), CCS (HR, 2.87; 95% CI, 1.96?4.18; p< 0.001), and OS (HR, 2.83; 95% CI, 1.96?4.07; p<0.001).
Conclusions: This study identified that PNLR ≥2.2 was usually associated with a poor prognosis for patients with VH-NMIBC.
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참고문헌 (29)
참고문헌 신청
Sung H / 2021 / Global cancer statistics 2020 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 71:209~249
Nielsen ME / 2014 / Trends in stage-specific incidence rates for urothelial carcinoma of the bladder in the United States : 1988 to 2006 / Cancer 120:86~95
Lenis AT / 2020 / Bladder cancer : a review / JAMA 324:1980~1991
Chiara Lonati / 2021 / Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy / European Urology Focus
Li D / 2020 / Clinical characteristics and prognosis of rare histological variants of bladder cancer : a single-center retrospective study from China / Cancer Manag Res 12:9635~9641
Nielsen ME / 2014 / Trends in stage-specific incidence rates for urothelial carcinoma of the bladder in the United States : 1988 to 2006 / Cancer 120:86~95
Lenis AT / 2020 / Bladder cancer : a review / JAMA 324:1980~1991
Chiara Lonati / 2021 / Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy / European Urology Focus
Li D / 2020 / Clinical characteristics and prognosis of rare histological variants of bladder cancer : a single-center retrospective study from China / Cancer Manag Res 12:9635~9641
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