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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 887 - 895 (9page)
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Background and Objectives Peroxiredoxin (Prx) is an antioxidant enzyme involved in signalingpathway. Prx2 is the most abundant in mammalian gray matter neurons and has protectiverole under oxidative stress. MUC5AC and MUC5B are typical mucin genes in human airwayepithelial cells. Even if free radicals play a key role in chronic respiratory inflammatorydiseases, the effects of the Prx2 on mucin expression and oxidative stress are not clearly known.
The purpose of this study is to investigate the effect of Prx2 on lipopolysaccharide (LPS)-inducedMUC5AC/5B expression and reactive oxygen species (ROS) in human airway epithelialcells.
Subjects and Method In NCI-H292 cells and human nasal epithelial cells, the effects ofPrx2 on LPS-induced MUC5AC/5B expression and ROS production were investigated usingreverse transcriptase-polymerase chain reaction, real-time polymerase chain reaction, enzymelinked immunosorbent assay (ELISA) and flow cytometry analysis.
Results MUC5AC, MUC5B mRNA expression and protein production were increased byLPS. ROS production was also increased by LPS. Prx2 suppressed the LPS-induced MUC5ACmRNA expression and protein production as well as ROS production. However, Prx2 did notinhibit MUC5B mRNA expression and protein production. N-acetylcysteine, diphenyleneiodonium,and apocynin also inhibited LPS-induced ROS production.
Conclusion These results may show that Prx2 suppresses LPS-induced MUC5AC expressionvia ROS in human airway epithelial cells.
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참고문헌 (26)
참고문헌 신청
Ishii T / 2012 / Novel roles of peroxiredoxins in inflammation, cancer and innate immunity / J Clin Biochem Nutr 50(2):91~105
Jin MH / 2005 / Characterization of neural cell types expressing peroxiredoxins in mouse brain / Neurosci Lett 381(3):252~257
Ali MS / 2007 / Upper airway mucin gene expression : A review / Laryngoscope 117(5):932~938
Fischer BM / 2002 / Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species / Am J Respir Cell Mol Biol 26(4):447~452
Hewson CA / 2004 / PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms / J Mol Biol 344(3):683~695
Jin MH / 2005 / Characterization of neural cell types expressing peroxiredoxins in mouse brain / Neurosci Lett 381(3):252~257
Ali MS / 2007 / Upper airway mucin gene expression : A review / Laryngoscope 117(5):932~938
Fischer BM / 2002 / Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species / Am J Respir Cell Mol Biol 26(4):447~452
Hewson CA / 2004 / PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms / J Mol Biol 344(3):683~695
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