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논문 기본 정보

자료유형
학술저널
저자정보
Kang Yu Min (Division of Infectious Diseases Department of Internal Medicine Myongji Hospital Goyang Korea.) Choe Kang-Won (Division of Infectious Diseases Department of Internal Medicine Myongji Hospital Goyang Korea.) Lee Ki-Deok (Division of Infectious Diseases Department of Internal Medicine Myongji Hospital Goyang Korea.) Kim Kwang Nam (Department of Pediatrics Myongji Hospital Goyang Korea.) Kim Moon Jung (Department of Laboratory Medicine Myongji Hospital Goyang Korea.) Lim Jaegyun (Department of Laboratory Medicine Myongji Hospital Goyang Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.35
발행연도
2021.9
수록면
1 - 6 (6page)
DOI
10.3346/jkms.2021.36.e250

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초록· 키워드

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There are still no agreed guidelines on the vaccination of coronavirus disease 2019 (COVID-19) for previously infected patients. Here, we present two seropositive healthcare workers (HCWs) working in an isolation ward who recovered from COVID-19 in April 2020 and got vaccinated with BNT162b2 vaccine in March 2021. We have assessed the clinical course, vaccine-related adverse events, and antibody response after natural infection and after first and second dose vaccination. One of the two HCWs was asymptomatic during quarantine, but the other had mild upper respiratory infection symptoms 1 day before admission, and the symptoms continued for 9 days. There was no pneumonic infiltration in chest X-ray in both patients, and no COVID-19 specific treatment was administered. Total immunoglobulin antibody and neutralizing antibody to anti-spike protein receptorbinding domain of severe acute respiratory syndrome coronavirus 2 were confirmed to be present in both HCWs in blood tests performed at 2 weeks and 4 weeks after discharge. Antibody response to mRNA vaccination showed marked elevation after the first vaccination, which was 30?40 times higher than that of antibody titer after natural infection in each patient (83.2 U/mL vs. > 2,500 U/mL in patient 1; 61.6 U/mL vs. > 2,500 U/mL in patient 2). Signal inhibition rate of neutralizing antibodies was also increased to over 97%. Due to this increased effect, there was little difference in antibody levels after the first and second dose. Both patients 1 and 2 suffered more from adverse vaccine reactions after the second vaccination than from COVID-19 symptoms.
#SARS-CoV-2 #COVID-19 Vaccine #Neutralizing Antibodies #BNT162b2 Vaccine

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참고문헌 (5)

참고문헌 신청
박만성 / 2021 / Neutralizing Antibody Responses to SARS-CoV-2 in Korean Patients Who Have Recovered from COVID-19 / Yonsei Medical Journal 62(7):584~592 dbpia Choe Pyoeng Gyun / 2021 / Antibody Responses One Year after Mild SARS-CoV-2 Infection / Journal of Korean Medical Science 36(21):1~4 dbpia Manisty C / 2021 / Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals / Lancet 397(10279):1057~1058 google schola Bradley T / 2021 / Antibody responses after a single dose of SARS-CoV-2 mRNA vaccine / N Engl J Med 384(20):1959~1961 google schola Tré-Hardy M / 2021 / Reactogenicity, safety and antibody response, after one and two doses of mRNA-1273 in seronegative and seropositive healthcare workers / J Infect 83(2):237~279 google schola

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