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논문 기본 정보

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학술저널
저자정보
Hur Young Min (Department of Obstetrics and Gynecology Ewha Womans University Mokdong Hospital Ewha Womans Univers) Mun Jaehee (Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul Korea.) Kim Mi-Kyung (Department of Obstetrics and Gynecology Ewha Womans University Mokdong Hospital Ewha Womans Univers) Lee Maria (Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul Korea.) Kim Yun Hwan (Department of Obstetrics and Gynecology Ewha Womans University Mokdong Hospital Ewha Womans Univers) Kim Seung-Cheol (Department of Obstetrics and Gynecology Ewha Womans University Mokdong Hospital Ewha Womans Univers)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.38
발행연도
2021.10
수록면
1 - 8 (8page)
DOI
10.3346/jkms.2021.36.e241

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Background: To assess the rate of germline BRCA gene tests in epithelial ovarian cancer (EOC) patients and uptake of post-test risk management strategies in BRCA1/2-mutated patients. Methods: Institutional databases were searched to identify patients who were diagnosed with epithelial ovarian, fallopian tube, or primary peritoneal cancer (EOC) between 2009 and 2019 in two academic hospitals. Retrospective review on medical records was performed to collect clinico-pathologic variables, including performance of germline BRCA gene test and its results, as well as conduct of breast cancer screening tests and cascade testing. If annual mammography +/? breast ultrasonography was performed, it was considered that regular breast cancer surveillance was done. Results: A total of 840 women with EOC were identified during the study period. Of these, 454 patients (54.0%) received BRCA gene testing and 106 patients (106/454, 23.3%) were positive for BRCA1/2 mutations. The rate of BRCA tests has markedly increased from 25.8% in 2009- 2012 to 62.7% in 2017-2019. Among the 93 patients with BRCA1/2 mutation without previous personal breast cancer history, 20 patients (21.5%) received annual mammography with or without breast ultrasonography for regular surveillance. Among the 106 BRCA1/2-mutated EOC patients, cascade testing on family members was performed only in 13 patients (12.3%). Conclusion: Although BRCA1/2 gene tests have been substantially expanded, the uptake of post-test risk management strategies, including breast cancer screening for BRCA1/2-mutated patients and cascade testing for family members, has remained low. Strategies to increase its uptake and education about the importance of post-test risk managements are needed.
#BRCA1 #BRCA2 #Epithelial Ovarian Cancer #Breast Cancer Screening #Cascade Test

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참고문헌 (17)

참고문헌 신청
Harter P / 2016 / BRCA1/2 mutations associated with progression-free survival in ovarian cancer patients in the AGO-OVAR 16 study / Gynecol Oncol 140(3):443~449 google schola Norquist BM / 2018 / Mutations in homologous recombination genes and outcomes in ovarian carcinoma patients in GOG 218 : an NRG Oncology/Gynecologic Oncology Group Study / Clin Cancer Res 24(4):777~783 google schola Daly MB / 2021 / Genetic/familial high-risk assessment : breast, ovarian, and pancreatic, version 2. 2021, NCCN clinical practice guidelines in oncology / J Natl Compr Canc Netw 19(1):77~102 google schola Domchek SM / 2019 / Update on genetic testing in gynecologic cancer / J Clin Oncol 37(27):2501~2509 google schola 이지현 / 2017 / Influence of the Angelina Jolie Announcement and Insurance Reimbursement on Practice Patterns for Hereditary Breast Cancer / Journal of Breast Cancer 20(2):203~207 dbpia

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