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논문 기본 정보

자료유형
학술저널
저자정보
Misra Durga Prasanna (Department of Clinical Immunology and Rheumatology Sanjay Gandhi Postgraduate Institute of Medical) Gasparyan Armen Yuri (Departments of Rheumatology and Research and Development Dudley Group NHS Foundation Trust (Teachin) Zimba Olena (Department of Internal Medicine #2 Danylo Halytsky Lviv National Medical University Lviv Ukraine.) Yessirkepov Marlen (Department of Biology and Biochemistry South Kazakhstan Medical Academy Shymkent Kazakhstan.) Agarwal Vikas (Department of Clinical Immunology and Rheumatology Sanjay Gandhi Postgraduate Institute of Medical) Kitas George D. (Departments of Rheumatology and Research and Development Dudley Group NHS Foundation Trust (Teachin)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.50
발행연도
2021.12
수록면
1 - 9 (9page)
DOI
10.3346/jkms.2021.36.e338

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Generating a testable working hypothesis is the first step towards conducting original research. Such research may prove or disprove the proposed hypothesis. Case reports, case series, online surveys and other observational studies, clinical trials, and narrative reviews help to generate hypotheses. Observational and interventional studies help to test hypotheses. A good hypothesis is usually based on previous evidence-based reports. Hypotheses without evidence-based justification and a priori ideas are not received favourably by the scientific community. Original research to test a hypothesis should be carefully planned to ensure appropriate methodology and adequate statistical power. While hypotheses can challenge conventional thinking and may be controversial, they should not be destructive. A hypothesis should be tested by ethically sound experiments with meaningful ethical and clinical implications. The coronavirus disease 2019 pandemic has brought into sharp focus numerous hypotheses, some of which were proven (e.g. effectiveness of corticosteroids in those with hypoxia) while others were disproven (e.g. ineffectiveness of hydroxychloroquine and ivermectin).

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