지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 997 - 1,004 (8page)
- DOI
- 10.3349/ymj.2021.62.11.997
이용수
초록· 키워드
오류제보하기
Purpose: This study aimed to determine whether the use of drugs in the treatment of inflammatory bowel disease is related to the risk of colorectal cancer using a Cox proportional hazards model with the landmark method to minimize immortal time bias.
Materials and Methods: This study was conducted as national cohort-based study using data from Korea’s Health Insurance Corporation. Newly diagnosed patients with inflammatory bowel disease from 2006 to 2010 were monitored for colorectal cancer until 2015. Hazard ratios and 95% confidence intervals were calculated and compared with the incidence of colorectal cancer with or without medications by applying various landmark points.
Results: In patients with Crohn’s disease, the prevention of colorectal cancer in the group exposed to immunomodulators was significant in the basic Cox model; however, the effect was not statistically significant in the model using the landmark method. The preventive effect of 5-aminosalicylic acid in patients with ulcerative colitis was significant in the basic and 6-month landmark point application models, but not in the remaining landmark application models.
Conclusion: In patients with inflammatory bowel disease, the preventive effect of drug exposure on colorectal cancer varies depending on the application of the landmark method. Hence, the possibility of immortal time bias should be considered.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Prada-Ramallal G / 2019 / Bias in pharmacoepidemiologic studies using secondary health care databases : a scoping review / BMC Med Res Methodol 19:53
van Walraven C / 2012 / Administrative database research has unique characteristics that can risk biased results / J Clin Epidemiol 65:126~131
Weiss NS / 2011 / The new world of data linkages in clinical epidemiology: are we being brave or foolhardy? / Epidemiology 22:292~294
Rothman KJ / 1998 / Modern epidemiology / Lippincott-Raven
Suissa S / 2003 / Effectiveness of inhaled corticosteroids in chronic obstructive pulmonary disease : immortal time bias in observational studies / Am J Respir Crit Care Med 168:49~53
van Walraven C / 2012 / Administrative database research has unique characteristics that can risk biased results / J Clin Epidemiol 65:126~131
Weiss NS / 2011 / The new world of data linkages in clinical epidemiology: are we being brave or foolhardy? / Epidemiology 22:292~294
Rothman KJ / 1998 / Modern epidemiology / Lippincott-Raven
Suissa S / 2003 / Effectiveness of inhaled corticosteroids in chronic obstructive pulmonary disease : immortal time bias in observational studies / Am J Respir Crit Care Med 168:49~53
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