지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 1,090 - 1,097 (8page)
- DOI
- 10.3349/ymj.2021.62.12.1090
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초록· 키워드
오류제보하기
Purpose: This study investigated the uptake rate of risk-reducing salpingo-oophorectomy (RRSO) and surgical outcomes of germline BRCA1/2 mutation carriers at Seoul National University Hospital (SNUH).
Materials and Methods: We examined the records of 824 women who underwent germline BRCA1/2 gene testing at SNUH between 2005 and 2020. Among them, we identified women with a pathogenic mutation on either the BRCA1 or the BRCA2 gene, and excluded ovarian cancer patients. Characteristics of participants who underwent RRSO (RRSO group) were compared to those who did not (non-RRSO group). Surgical outcomes and pathologic results were investigated in the RRSO group.
Results: There were 117 BRCA1/2 mutation carriers included in the analysis. The uptake rate of RRSO was 70.1% (82/117). Older age (mean: 48.8 years vs. 42.1 years; p=0.002) and higher employment rate (65.9% vs. 14.3%; p<0.001) were observed in the RRSO group compared to the non-RRSO group. However, no differences in other factors, such as personal and family history of breast cancer, were observed between the two groups. In the RRSO group, the median time interval between the genetic test and RRSO was 10.0 months, and there were three (3.7%) incidental cases of high-grade serous carcinoma. However, one patient in the non-RRSO group developed primary peritoneal cancer after 103.8 months of surveillance.
Conclusion: The uptake rate of RRSO in BRCA1/2 mutation carriers was about 70%. Considering incidental cancer cases in women without abnormal findings on preoperative evaluation, BRCA1/2-mutated women might refrain from the delayed implementation of RRSO after the genetic test.
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참고문헌 (24)
참고문헌 신청
Sung H / 2021 / Global cancer statistics 2020 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 71:209~249
Committee on Practice Bulletins–Gynecology / 2017 / Practice Bulletin No 182 : hereditary breast and ovarian cancer syndrome / Obstet Gynecol 130:e110~e126
Menon U / 2018 / Ovarian cancer prevention and screening / Obstet Gynecol 131:909~927
Antoniou A / 2003 / Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history : a combined analysis of 22 studies / Am J Hum Genet 72:1117~1130
Daly MB / 2020 / NCCN guidelines insights: genetic/familial high-risk assessment: breast, ovarian, and pancreatic, version 1.2020: featured updates to the NCCN guidelines / J Natl Compr Canc Netw 18:380~391
Committee on Practice Bulletins–Gynecology / 2017 / Practice Bulletin No 182 : hereditary breast and ovarian cancer syndrome / Obstet Gynecol 130:e110~e126
Menon U / 2018 / Ovarian cancer prevention and screening / Obstet Gynecol 131:909~927
Antoniou A / 2003 / Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history : a combined analysis of 22 studies / Am J Hum Genet 72:1117~1130
Daly MB / 2020 / NCCN guidelines insights: genetic/familial high-risk assessment: breast, ovarian, and pancreatic, version 1.2020: featured updates to the NCCN guidelines / J Natl Compr Canc Netw 18:380~391
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