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논문 기본 정보

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학술저널
저자정보
이창한 (경상국립대학교) Hyeong Seop Kim (Gyeongsang National University Hospital) Young-Soo Kim (Gyeongsang National University Hospital) Seokwon Jung (Gyeongsang National University Hospital) 윤철호 (경상국립대학교) Oh-Young Kwon (Gyeongsang National University Hospital)
저널정보
대한통증학회 The Korean Journal of Pain The Korean Journal of Pain 제34권 제4호
발행연도
2021.10
수록면
437 - 446 (10page)
DOI
10.3344/kjp.2021.34.4.437

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Background: Non-invasive painless signaling therapy (NPST) is an electro-cutaneous treatment that converts endogenous pain information into synthetic non-pain information. This study explored whether pain improvement by NPST in failed back surgery syndrome (FBSS) patients is related to cerebral modulation. Methods: Electroencephalography (EEG) analysis was performed in 11 patients with FBSS. Subjects received daily NPST for 5 days. Before the first treatment, patients completed the Brief Pain Inventory (BPI) and Beck Depression Inventory and underwent baseline EEG. After the final treatment, they responded again to the BPI, reported the percent pain improvement (PPI), and then underwent post-treatment EEG. If the PPI grade was zero, they were assigned to the ineffective group, while all others were assigned to the effective group. We used standardized low-resolution brain electromagnetic tomography (sLORETA) to explore the EEG current-source distribution (CSD) associated with pain improvement by NPST. Results: The 11 participants had a median age of 67.0 years, and 63.6% were female. The sLORETA images revealed a beta-2 CSD increment in 12 voxels of the right anterior cingulate gyrus (ACG) and the right medial frontal area. The point of maximal CSD changes was in the right ACG. The alpha band CSD increased in 2 voxels of the left transverse gyrus. Conclusions: Pain improvement by NPST in FBSS patients was associated with increased cerebral activity, mainly in the right ACG. The change in afferent information induced by NPST seems to be associated with cerebral pain perception.

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