지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 65 - 75 (11page)
- DOI
- 10.5125/jkaoms.2021.47.2.65
이용수
초록· 키워드
오류제보하기
Medication-related osteonecrosis of the jaw (MRONJ) has recently associated to the increase in antiresorptive and anti-angiogenic drugs prescriptions in the treatment of oncologic and osteoporotic patients. The physiopathogenesis of MRONJ remains unclear and available treatments are unsatisfactory. Newer pharmacological treatments have shown good results, but are not curative and could have major side effects. At the same time as pharmacologi-cal treatments, mesenchymal stem cells (MSCs) have emerged as a promising therapeutic modality for tissue regeneration and repair. MSCs are multi-potential non-hematopoietic progenitor cells capable to differentiating into multiple lineages of the mesenchyme. Bone marrow MSCs can differentiate into osteogenic cells and display immunological properties and secrete paracrine anti-inflammatory factors in damaged tissues. The immunomodula-tory, reparative, and anti-inflammatory properties of bone marrow MSCs have been tested in a variety of animal models of MRONJ and applied in specific clinical settings. The aim of this review is to discuss critically the immunogenicity and immunomodulatory properties of MSCs, both in vitro and in vivo, the possible underlying mechanisms of their effects, and their potential clinical use as modulators of immune responses in MRONJ, and to identify clinical safety and recommendations for future research.
목차
등록된 정보가 없습니다.
참고문헌 (96)
참고문헌 신청
Robert E Marx / 2003 / Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic / Journal of Oral and Maxillofacial Surgery 61(9):1115~1117
Salvatore L. Ruggiero / 2014 / American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw—2014 Update / Journal of Oral and Maxillofacial Surgery 72(10):1938~1956
Victoria Rollason / 2016 / Interventions for treating bisphosphonate-related osteonecrosis of the jaw (BRONJ) / Cochrane Database of Systematic Reviews 2016(2)
Lombard T / 2016 / Medication-related osteonecrosis of the jaw : new insights into molecular mechanisms and cellular therapeutic approaches / Stem Cells Int 2016:8768162
Leonzio Fortunato / 2020 / Is the application of platelet concentrates effective in the prevention and treatment of medication-related osteonecrosis of the jaw? A systematic review / Journal of Cranio-Maxillofacial Surgery 48(3):268~285
Salvatore L. Ruggiero / 2014 / American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw—2014 Update / Journal of Oral and Maxillofacial Surgery 72(10):1938~1956
Victoria Rollason / 2016 / Interventions for treating bisphosphonate-related osteonecrosis of the jaw (BRONJ) / Cochrane Database of Systematic Reviews 2016(2)
Lombard T / 2016 / Medication-related osteonecrosis of the jaw : new insights into molecular mechanisms and cellular therapeutic approaches / Stem Cells Int 2016:8768162
Leonzio Fortunato / 2020 / Is the application of platelet concentrates effective in the prevention and treatment of medication-related osteonecrosis of the jaw? A systematic review / Journal of Cranio-Maxillofacial Surgery 48(3):268~285
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