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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 291 - 314 (24page)
- DOI
- 10.5125/jkaoms.2021.47.4.291
이용수
초록· 키워드
오류제보하기
Squamous cell carcinoma (SCC) of the retromolar trigone (RMT) is a rare but potentially fatal disease that carries a poor prognosis due to its unique anatomic position. RMT SCCs tend to spread to vital nearby structures, including the tonsillar pillar, masticatory muscles, and underlying mandibular bone, even in their early stages, and aggressive treatment is often warranted. This systematic review appraises and qualitatively analyzes all available literature regarding the survival outcomes and prognosis of RMT SCC. Four databases were searched to identify all eligible articles published since January 1980. Of the 1,248 studies, a total of 15 studies representing 4,838 cases met the inclusion criteria. The evaluated patients had a high rate of advanced tumor stage (T3 or T4: 61.4%), lymph node metastasis (38.8%), and mandibular bone invasion (24%) at the time of diagnosis. Aggressive surgical treatments such as lip-splitting (92%), segmental mandibulectomy (61.1%), radical neck dissection (44.1%), and reconstruction using free flaps (49.5%) was undertaken for 92% of the pooled patient population. The mean rates for local, regional, and systemic recurrence were 23.40%, 8.40%, and 8.50%, respectively. The mean 5-year overall survival rate was 38.90%. Osteonecrosis was noted in 11.6% of the 328 patients who received radiotherapy. In conclusion, RMT SCC is generally associated with high recurrence, low survival, and high postoperative complication rates. Early diagnosis and aggressive treatment are thus warranted. However, significant methodological problems hamper current knowledge. Future studies of this topic that use randomized or cohort designs are thus needed.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Zachary Farhood / 2019 / Does anatomic subsite influence oral cavity cancer mortality? A SEER database analysis / The Laryngoscope 129(6):1400~1406
Alexander L. Luryi / 2014 / Positive Surgical Margins in Early Stage Oral Cavity Cancer / Otolaryngology–Head and Neck Surgery 151(6):984~990
Justin C. Sowder / 2017 / Treatment-related determinants of survival in early-stage (T1-2N0M0) oral cavity cancer: A population-based study / Head & Neck 39(5):876~880
S K Mukherji / 1997 / Imaging squamous cell carcinomas of the upper aerodigestive tract: what clinicians need to know. / Radiology 205(3):629~646
Alessandro Liberati / 2009 / The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration / Journal of Clinical Epidemiology 62(10):e1~e34
Alexander L. Luryi / 2014 / Positive Surgical Margins in Early Stage Oral Cavity Cancer / Otolaryngology–Head and Neck Surgery 151(6):984~990
Justin C. Sowder / 2017 / Treatment-related determinants of survival in early-stage (T1-2N0M0) oral cavity cancer: A population-based study / Head & Neck 39(5):876~880
S K Mukherji / 1997 / Imaging squamous cell carcinomas of the upper aerodigestive tract: what clinicians need to know. / Radiology 205(3):629~646
Alessandro Liberati / 2009 / The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration / Journal of Clinical Epidemiology 62(10):e1~e34
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