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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.4
- 수록면
- 152 - 158 (7page)
- DOI
- https://doi.org/10.3904/kjm.2019.94.2.152
이용수
초록· 키워드
오류제보하기
CD19 chimeric antigen receptor T-cell (CAR-T) therapy, a genetically engineered cell therapy, showed unprecedented efficacy in the treatment of relapsed or refractory diffuse large B-cell lymphoma. Two agents, axicabtagene ciloleucel and tisagenlecleucel, were approved by the Food and Drug Administration in 2017. However, CAR-T therapy is a treatment with complex logistics and high costs, as well as inherent adverse events, including cytokine-release syndrome and neurotoxicity. In addition, predictive biomarkers for efficacy and toxicity are lacking. Industry-academy cooperation is urgently required to develop CAR-T therapy that is effective, safe, and affordable for patients in Korea.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
정규원 / 2018 / Prediction of Cancer Incidence and Mortality in Korea, 2018 / Cancer Research and Treatment 50(2):317~323
김진만 / 2011 / WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study / Journal of Pathology and Translational Medicine 45(3):254~260
Sehn LH / 2015 / Diffuse large B-cell lymphoma : optimizing outcome in the context of clinical and biologic heterogeneity / Blood 125:22~32
Gisselbrecht C / 2010 / Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era / J Clin Oncol 28:4184~4190
Crump M / 2017 / Outcomes in refractory diffuse large B-cell lymphoma : results from the international SCHOLAR-1 study / Blood 130:1800~1808
김진만 / 2011 / WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study / Journal of Pathology and Translational Medicine 45(3):254~260
Sehn LH / 2015 / Diffuse large B-cell lymphoma : optimizing outcome in the context of clinical and biologic heterogeneity / Blood 125:22~32
Gisselbrecht C / 2010 / Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era / J Clin Oncol 28:4184~4190
Crump M / 2017 / Outcomes in refractory diffuse large B-cell lymphoma : results from the international SCHOLAR-1 study / Blood 130:1800~1808
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