지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 371 - 381 (11page)
- DOI
- https://doi.org/10.3904/kjm.2021.96.5.371
이용수
초록· 키워드
오류제보하기
Monoclonal gammopathy (MG) encompasses a diverse group of disorders characterized by the secretion of monoclonal immunoglobulins or their light-chain components. The incidence of multiple myeloma (MM) in South Korea is rapidly increasing, and it is important to be aware of its initial clinical presentations and the most efficient laboratory algorithms for early detection.
Serum protein electrophoresis (SPE) and urine protein electrophoresis (UPE) are the primary screening tests for patients with clinically suspected MM or amyloid light-chain amyloidosis; these tests are reimbursed in South Korea. We reviewed clinical studies that applied national and international guidelines to evaluate test panels for early detection of MGs, including MM. The serum free light chain (sFLC) with SPE panel is recommended for the initial work up for diagnosis of MGs. In the case of a normal SPE, sFLC should be measured subsequently, so as not to miss the presence of M-protein. Use of this screening panel avoids medical expenses related to delayed diagnosis. Guidelines and recommendations suggest that no single method (SPE, serum immunofixation electrophoresis, sFLC, or UPE) should be used to exclude a diagnosis of MM. We believe that a screening test panel comprising SPE plus sFLC will increase the rate of early and accurate diagnosis of MM and related disorders.
목차
등록된 정보가 없습니다.
참고문헌 (81)
참고문헌 신청
Kyle RA / 2006 / Monoclonal gammopathy of undetermined significance / Br J Haematol 134:573~589
Kim YR / 2014 / Monoclonal and polyclonal gammopathy measured by serum free light chain and immunofixation subdivide the clinical outcomes of diffuse large B-cell lymphoma according to molecular classification / Ann Hematol 93:1867~1877
Witzig TE / 2014 / Elevated monoclonal and polyclonal serum immunoglobulin free light chain as prognostic factors in B-and T-cell non-Hodgkin lymphoma / Am J Hematol 89:1116~1120
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386
Siegel RL / 2015 / Cancer statistics, 2015 / CA Cancer J Clin 65:5~29
Kim YR / 2014 / Monoclonal and polyclonal gammopathy measured by serum free light chain and immunofixation subdivide the clinical outcomes of diffuse large B-cell lymphoma according to molecular classification / Ann Hematol 93:1867~1877
Witzig TE / 2014 / Elevated monoclonal and polyclonal serum immunoglobulin free light chain as prognostic factors in B-and T-cell non-Hodgkin lymphoma / Am J Hematol 89:1116~1120
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386
Siegel RL / 2015 / Cancer statistics, 2015 / CA Cancer J Clin 65:5~29
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