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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제1호
- 발행연도
- 2017.1
- 수록면
- 27 - 36 (10page)
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Angelicae Gigantis Radix (AGR, Angelica gigas ) has been used for a long time as a traditional folk medicine in Korea and oriental countries. Decursinol angelate (DCA) is structurally isomeric decursin, one of the major components of AGR. This study was performed to confirm whether DCA augments pentobarbitalinduced sleeping behaviors via the activation of GABAA-ergic systems in animals.
Oral administration of DCA (10, 25 and 50 mg/kg) markedly suppressed spontaneous locomotor activity. DCA also prolonged sleeping time, and decreased the sleep latency by pentobarbital (42 mg/kg), in a dose-dependent manner, similar to muscimol, both at the hypnotic (42 mg/kg) and sub-hypnotic (28 mg/kg) dosages.
Especially, DCA increased the number of sleeping animals in the sub-hypnotic dosage. DCA (50 mg/kg, p.o.) itself modulated sleep architectures; DCA reduced the counts of sleep/wake cycles. At the same time, DCA increased total sleep time, but not non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. In the molecular experiments. DCA (0.001, 0.01 and 0.1 μg/ml) increased intracellular Cl- influx level in hypothalamic primary cultured neuronal cells of rats. In addition, DCA increased the protein expression of glutamic acid decarboxylase (GAD65/67) and GABAA receptors subtypes. Taken together, these results suggest that DCA potentiates pentobarbital-induced sleeping behaviors through the activation of GABAA-ergic systems, and can be useful in the treatment of insomnia.
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참고문헌 (52)
참고문헌 신청
Chung-Soo Kim / 2011 / Herbs for the Treatment of Insomnia / Biomolecules & Therapeutics 19(3):274~281
Jiang X / 2015 / Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1polarization of macrophages / Clin Immunol 160:328~335
Pu L / 2012 / Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor / Evid Based Complement Alternat Med 2012:818451
Hajak G / 2001 / Doxepin in the treatment of primary insomnia : a placebo-controlled, double-blind, polysomnographic study / J Clin Psychiatry 62:453~463
Barnard EA / 1998 / International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function / Pharmacol Rev 50:291~313
Jiang X / 2015 / Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1polarization of macrophages / Clin Immunol 160:328~335
Pu L / 2012 / Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor / Evid Based Complement Alternat Med 2012:818451
Hajak G / 2001 / Doxepin in the treatment of primary insomnia : a placebo-controlled, double-blind, polysomnographic study / J Clin Psychiatry 62:453~463
Barnard EA / 1998 / International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function / Pharmacol Rev 50:291~313
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