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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제2호
- 발행연도
- 2017.3
- 수록면
- 267 - 273 (7page)
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초록· 키워드
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The p53-inducible gene 3 (PIG3), initially identified as a gene downstream of p53, plays an important role in the apoptotic process triggered by p53- mediated reactive oxygen species (ROS) production. Recently, several studies have suggested that PIG3 may play a role in various types of cancer. However, the functional significance of PIG3 in cancer remains unclear. Here, we found that PIG3 was highly expressed in human colon cancer cell lines compared to normal colonderived fibroblasts. Therefore, we attempted to elucidate the functional role of PIG3 in colon cancer. PIG3 overexpression increases the colony formation, migration and invasion ability of HCT116 colon cancer cells. Conversely, these tumorigenic abilities were significantly decreased in in vitro studies with PIG3 knockdown HCT116 cells.
PIG3 knockdown also attenuated the growth of mouse xenograft tumors. These results demonstrate that PIG3 is associated with the tumorigenic potential of cancer cells, both in vitro and in vivo, and could play a key oncogenic role in colon cancer.
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등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Polyak K / 1997 / A model for p53-induced apoptosis / Nature 389:300~305
Johnson TM / 1996 / Reactive oxygen species are downstream mediators of p53-dependent apoptosis / Proc Natl Acad Sci U S A 93:11848~11852
Contente A / 2002 / A polymorphic microsatellite that mediates induction of PIG3 by p53 / Nat Genet 30:315~320
Porté S / 2009 / Threedimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3 / J Biol Chem 284:17194~17205
Siegel D / 2004 / NAD(P)H : quinone oxidoreductase 1 : role as a superoxide scavenger / Mol Pharmacol 65:1238~1247
Johnson TM / 1996 / Reactive oxygen species are downstream mediators of p53-dependent apoptosis / Proc Natl Acad Sci U S A 93:11848~11852
Contente A / 2002 / A polymorphic microsatellite that mediates induction of PIG3 by p53 / Nat Genet 30:315~320
Porté S / 2009 / Threedimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3 / J Biol Chem 284:17194~17205
Siegel D / 2004 / NAD(P)H : quinone oxidoreductase 1 : role as a superoxide scavenger / Mol Pharmacol 65:1238~1247
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