지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제5호
- 발행연도
- 2017.9
- 수록면
- 457 - 464 (8page)
이용수
초록· 키워드
오류제보하기
Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD- 50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG) animals were given single oral doses of distilled water as a solvent. TTD, ETD-50 and ETD-100 groups were subjected to 720o degrees torsion for four hours, and detorsion for four hours. The SOG group was not subjected to this procedure.
Biochemical, gene expression and histopathological analyses were carried out on the testicular tissues. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) were significantly higher, and the levels of total glutathione (tGSH) and glutathione reductase (GSHRd) were significantly lower in the TTD group, compared to the ETD-50, ETD-100 and SOG groups. Etoricoxib at a dose of 100 mg/kg better prevented I/R damage than the 50 mg/kg dose. Etoricoxib may be useful in clinical practice in the reduction of I/ R damage on testes caused by torsion-detorsion.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Yapca OE / 2013 / Ischemia-reperfusion damage / Eurasian J Med 45:126~127
Parks DA / 1983 / Ischemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals / Am J Physiol 245:G285~G289
Del Maestro RF / 1980 / An approach to free radicals in medicine and biology / Acta Physiol Scand Suppl 492:153~168
Tuglu D / 2015 / The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury / Acta Cir Bras 30:414~421
Cvetkovic T / 2015 / Oxidant and antioxidant status in experimental rat testis after testicular torsion/detorsion / Int J Fertil Steril 9:121~128
Parks DA / 1983 / Ischemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals / Am J Physiol 245:G285~G289
Del Maestro RF / 1980 / An approach to free radicals in medicine and biology / Acta Physiol Scand Suppl 492:153~168
Tuglu D / 2015 / The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury / Acta Cir Bras 30:414~421
Cvetkovic T / 2015 / Oxidant and antioxidant status in experimental rat testis after testicular torsion/detorsion / Int J Fertil Steril 9:121~128
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Clinical outcomes of sigmoid colon volvulus: identification of the factors associated with successful endoscopic detorsion
Intestinal research
2017 .01
-
Establishing and characterizing the clinical simulation of testicle torsion in rat model
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Measurement of the Optic Nerve Sheath Diameter with Magnetic Resonance Imaging and Its Association with Eyeball Diameter in Healthy Adults
Journal of Clinical Neurology
2018 .01
-
The incidence of testicular torsion and testicular salvage rate in Korea over 10 years: A nationwide population-based study
Investigative and Clinical Urology
2022 .07
-
Non-invasive evaluation of testicular torsion using ultrasound shear wave elastography: an experimental study
ULTRASONOGRAPHY
2024 .03
-
Investigation on efficacy of pterostilbene for testicular ischemia-reperfusion animal model
한국실험동물학회 학술발표대회 논문집
2015 .02
-
The authors reply: Predictive role of hematologic parameters in testicular torsion
Investigative and Clinical Urology
2015 .01
-
Efficacy of Pterostilbene in a Testicular Ischemia/Reperfusion Animal Model
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Navigation-Assisted Balloon Eustachian Tuboplasty for Eustachian Tube Dilatory Dysfunction
Clinical and Experimental Otorhinolaryngology
2020 .01
-
Letter to the editor: Predictive value of the neutrophil-lymphocyte ratio and mean platelet volume in testicular torsion
Investigative and Clinical Urology
2015 .01
-
Treatment of Surgical Site Infection in Posterior Lumbar Interbody Fusion
Asian Spine Journal
2015 .01
-
China dust exposure increases the testicular damage that cyclophosphamide causes in mice
한국실험동물학회 학술발표대회 논문집
2023 .02
-
Trends in Testicular Injury in Korea, 1986–2015
Journal of Korean Medical Science
2017 .01
-
Successful onco-testicular sperm extraction from a testicular cancer patient with a single testis and azoospermia
Clinical and experimental reproductive medicine : CERM
2018 .01
-
Effects of hyperbaric oxygen and iloprost on intestinal ischemia-reperfusion induced acute lung injury
Annals of Surgical Treatment and Research
2019 .01
-
Ischemia reperfusion injury of liver and development of an experimental platform
한국실험동물학회 학술발표대회 논문집
2020 .07
-
A Case of Functional Testicular Torsion Caused by Incarcerated Inguinal Hernia in a Newborn
Neonatal medicine
2021 .11
-
Evaluation of the Effect of Pentoxifylline on Cisplatin-Induced Testicular Toxicity in Rats
Toxicological Research
2017 .06
-
The expression of sal-like protein 4 in porcine testicular development
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Efficacy study of Angelica gigas in a rat myocardial ischemia/reperfusion injury model
한국실험동물학회 학술발표대회 논문집
2023 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0