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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제5호
- 발행연도
- 2017.09
- 수록면
- 547 - 554 (8page)
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초록· 키워드
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Previous studies have demonstrated the role of hydroquinone (HQ), a hydroxylated benzene metabolite, in modulating various immune responses; however, its role in macrophage-mediated inflammatory responses is not fully understood. In this study, the role of HQ in inflammatory responses and the underlying molecular mechanism were explored in macrophages. HQ down-regulated the expression of interferon (IFN)-b mRNA in LPS-stimulated RAW264.7 cells without any cytotoxicity and suppressed interferon regulatory factor (IRF)-3-mediated luciferase activity induced by TIR-domain-containing adapter-inducing interferon-β (TRIF) and TANK-binding kinase 1 (TBK1). A mechanism study revealed that HQ inhibited IRF-3 phosphorylation induced by lipopolysaccharide (LPS), TRIF, and AKT by suppressing phosphorylation of AKT, an upstream kinase of the IRF-3 signaling pathway. IRF-3 phosphorylation is highly induced by wild-type AKT and poorly induced by an AKT mutant, AKT C310A, which is mutated at an inhibitory target site of HQ. We also showed that HQ inhibited IRF-3 phosphorylation by targeting all three AKT isoforms (AKT1, AKT2, and AKT3) in RAW264.7 cells and suppressed IRF-3-mediated luciferase activities induced by AKT in HEK293 cells. Taken together, these results strongly suggest that HQ inhibits the production of a type I IFN, IFN-b, by targeting AKTs in the IRF-3 signaling pathway during macrophage-mediated inflammation.
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참고문헌 (38)
참고문헌 신청
Ferrero-Miliani L / 2007 / Chronic inflammation : importance of NOD2 and NALP3 in interleukin-1beta generation / Clin Exp Immunol 147:227~235
Kaur M / 2013 / Inhibitors of switch kinase ‘spleen tyrosine kinase’ in inflammation and immune-mediated disorders : a review / Eur J Med Chem 67:434~446
Kwang-Soo Baek / 2016 / In vitro and in vivo anti-inflammatory activities of Korean Red Ginseng-derived components / Journal of Ginseng Research 40(4):437~444
Vance RE / 2009 / Patterns of pathogenesis : discrimination of pathogenic and nonpathogenic microbes by the innate immune system / Cell Host Microbe 6:10~21
Janeway CA Jr / 2002 / Innate immune recognition / Annu Rev Immunol 20:197~216
Kaur M / 2013 / Inhibitors of switch kinase ‘spleen tyrosine kinase’ in inflammation and immune-mediated disorders : a review / Eur J Med Chem 67:434~446
Kwang-Soo Baek / 2016 / In vitro and in vivo anti-inflammatory activities of Korean Red Ginseng-derived components / Journal of Ginseng Research 40(4):437~444
Vance RE / 2009 / Patterns of pathogenesis : discrimination of pathogenic and nonpathogenic microbes by the innate immune system / Cell Host Microbe 6:10~21
Janeway CA Jr / 2002 / Innate immune recognition / Annu Rev Immunol 20:197~216
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