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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제2호
- 발행연도
- 2018.3
- 수록면
- 183 - 192 (10page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.2.183
이용수
초록· 키워드
오류제보하기
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear circuit. The present study measured several anxiety-related behavioral responses to examine the effects of berberine (BER) on symptoms of anxiety in rats after single prolonged stress (SPS) exposure, and to determine if BER reversed the dopamine (DA) dysfunction. Rats received BER (10, 20, or 30 mg/kg, intraperitoneally, once daily) for 14 days after SPS exposure. BER administration significantly increased the time spent in the open arms and reduced grooming behavior during the elevated plus maze test, and increased the time spent in the central zone and the number of central zone crossings in the open field test. BER restored neurochemical abnormalities and the SPS-induced decrease in DA tissue levels in the hippocampus and striatum. The increased DA concentration during BER treatment may partly be attributed to mRNA expression of tyrosine hydroxylase and the DA transporter in the hippocampus, while BER exerted no significant effects on vesicular monoamine transporter mRNA expression in the hippocampus of rats with PTSD. These results suggest that BER had anxiolytic-like effects on behavioral and biochemical measures associated with anxiety.
These findings support a role for reduced anxiety altered DAergic transmission and reduced anxiety in rats with PTSD. Thus, BER may be a useful agent to treat or alleviate psychiatric disorders like those observed in patients with PTSD.
목차
등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Enman NM / 2015 / Anhedonia, reduced cocaine reward, and dopamine dysfunction in a rat model of posttraumatic stress disorder / Biol Psychiatry 78:871~879
Wilson CB / 2014 / Predator exposure/psychosocial stress animal model of post-traumatic stress disorder modulates neurotransmitters in the rat hippocampus and prefrontal cortex / PLoS One 9:e89104
Ji LL / 2014 / Intra-hippocampal administration of ZIP alleviates depressive and anxietylike responses in an animal model of posttraumatic stress disorder / Behav Brain Funct :10~28
Rau V / 2005 / Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder / Neurosci Biobehav Rev 29:1207~1223
Shin LM / 2010 / The neurocircuitry of fear, stress, and anxiety disorders / Neuropsychopharmacology 35:169~191
Wilson CB / 2014 / Predator exposure/psychosocial stress animal model of post-traumatic stress disorder modulates neurotransmitters in the rat hippocampus and prefrontal cortex / PLoS One 9:e89104
Ji LL / 2014 / Intra-hippocampal administration of ZIP alleviates depressive and anxietylike responses in an animal model of posttraumatic stress disorder / Behav Brain Funct :10~28
Rau V / 2005 / Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder / Neurosci Biobehav Rev 29:1207~1223
Shin LM / 2010 / The neurocircuitry of fear, stress, and anxiety disorders / Neuropsychopharmacology 35:169~191
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