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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 830 - 840 (11page)
- DOI
- 10.9799/ksfan.2017.30.4.830
이용수
초록· 키워드
오류제보하기
Excessive body weight gain during the growth period of early life may predispose individuals towards obesity and metabolic disorder in later life. We investigated the possibility of using the food efficiency ratio as an early indicator for predicting susceptibility to diet-induced obesity and insulin resistance. Four-week-old, prepubertal, male Sprague Dawley rats were divided into obesity-prone and obesity-resistant groups based on food efficiency ratio values after five days on a high-fat diet. Metabolic parameters measured after 2, 6, and 10 weeks, and specific phenotypes were compared with each group. Obesity- prone rats had higher increases in body weight and fat mass compared to obesity-resistant rats over the study period. Obesity-prone rats became glucose intolerant early in this study and remained so throughout the experimental period, with increases in fat weight and leptin levels occurring first, followed by increases in insulin level. Gluconeogenesis and insulin resistance significantly increased in obesity-prone groups in which activities of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase were increased and glucokinase activity decreased. Higher food efficiency ratio at an early age was closely correlated with body fat accumulation, hyperleptinemia, and hyperinsulinemia of middle and elderly age. We suggest a high food efficiency ratio in prepubertal subjects may be a useful predictor of future obesity and insulin resistance.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Aas AM / 2009 / Insulin-stimulated increase in serum leptin levels precedes and correlates with weight gain during insulin therapy in type 2 diabetes / J Clin Endocrinol Metab 94:2900~2906
Alexander J / 2006 / Distinct phenotypes of obesity-prone AKR/J, DBA2J and C57BL/6J mice compared to control strains / Int J Obes 30:50~59
Baginski / 1974 / Methods of Enzymatic Analysis / Academic Press :876
Bentla LA / 1976 / Interaction of anions and divalent metal ions with phosphoenolpyruvate carboxykinase / J Biol Chem 251:2916~2921
Björnholm M / 2007 / Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function / J Clinical Invest 117:1354~1360
Alexander J / 2006 / Distinct phenotypes of obesity-prone AKR/J, DBA2J and C57BL/6J mice compared to control strains / Int J Obes 30:50~59
Baginski / 1974 / Methods of Enzymatic Analysis / Academic Press :876
Bentla LA / 1976 / Interaction of anions and divalent metal ions with phosphoenolpyruvate carboxykinase / J Biol Chem 251:2916~2921
Björnholm M / 2007 / Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function / J Clinical Invest 117:1354~1360
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