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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 112 - 116 (5page)
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Hyperammonemia is mainly caused by diseases related to liver failure. However, there are also non-hepatic causes of hyperammonemia, such as urinary tract infection (UTI) due to urease-producing organisms. Urease production by these bacteria induces a hydrolysis of urinary urea into ammonia that can cross the urothelial cell membrane and diffuse into blood vessels, leading to hyperammonemia. Delayed diagnosis and treatment of hyperammonemia can lead to lethal encephalopathy that can cause brain damage and life-threatening conditions. In the presence of obstructive uropathy, UTI by urease-producing bacteria can lead to more severe hyperammonemia due to enhanced resorption of ammonia into the systemic circulation. In this report, we present a case of acute severe hyperammonemic encephalopathy leading to brain death due to accumulation of ammonia in blood caused by Morganella morganii UTI in a 10-year-old girl with cloacal anomaly, causing obstructive uropathy even after multiple corrections.
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등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Burton BK / 2000 / Urea cycle disorders / Clin Liver Dis 4:815~830
Savy N / 2018 / Acute pediatric hyperammonemia : current diagnosis and management strategies / Hepatic Med Evid Res 10:105~115
Kaveggia FF / 1990 / Hyperammonemic encephalopathy in urinary diversion with ureasplitting urinary tract infection / Arch Intern Med 150:2389~2392
Warne S / 2002 / Prenatal diagnosis of cloacal anomalies / BJU Int 89:78~81
Ozanne B / 2012 / Threshold for toxicity from hyperammonemia in critically ill children / J Hepatol 56:123~128
Savy N / 2018 / Acute pediatric hyperammonemia : current diagnosis and management strategies / Hepatic Med Evid Res 10:105~115
Kaveggia FF / 1990 / Hyperammonemic encephalopathy in urinary diversion with ureasplitting urinary tract infection / Arch Intern Med 150:2389~2392
Warne S / 2002 / Prenatal diagnosis of cloacal anomalies / BJU Int 89:78~81
Ozanne B / 2012 / Threshold for toxicity from hyperammonemia in critically ill children / J Hepatol 56:123~128
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