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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 137 - 143 (7page)
- DOI
- https://doi.org/10.1186/s40824-017-0103-9
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초록· 키워드
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Background: Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional functional groups to the block copolymers, we can achieve advanced applications. In this regards, we tried to introduce aggregation induced emission enhancement (AIE) unit in the block copolymer. Methods: The formation of polyion complex micelle was confirmed by dynamic light scattering and transmission electron microscopy. HeLa cells were incubated with polyion complex micelle and broad-band visible light using a halogen lamp (150 W) was irradiated to evaluate photocytotoxicity of polyion complex (PIC) micelle. Results: For the design of functional polymeric micelle, aggregation induced emission enhancement unit was introduced in the middle of block copolymer. We newly synthesized a new type block copolymer (PEG-TPE-PEI) possessing tetraphenylethene (TPE) group, as an AIE unit, in the middle of polymeric segments of PEG and PEI, which successfully formed PIC micelle with DP. The formation of PIC micelle was confirmed by dynamic light scattering, ζ potential measurement and transmission electron microscopy. Conclusions: PEG-TPE-PEI successfully formed PIC micelle by mixing with negatively charged dendrimer porphyrin. The PIC micelle exhibited photocytotoxicity upon illumination of broadband visible light.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Kwon GS / 1996 / Polymeric micelles as new drug carriers / Adv Drug Deliv Rev 21:107~116
Kataoka K / 2001 / Block copolymer micelles for drug delivery:design, characterization and biological significance / Adv Drug Deliv Rev 47:113~131
Zeeshan Sheikh / 2017 / Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review / 생체재료학회지 21(2):17~36
Harada A / 1995 / Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments / Macromolecules 28:5294~5299
Yoon H / 2014 / Polymeric supramolecular assemblies based on multivalent ionic interactions for biomedical applications / Polymer 55:453~464
Kataoka K / 2001 / Block copolymer micelles for drug delivery:design, characterization and biological significance / Adv Drug Deliv Rev 47:113~131
Zeeshan Sheikh / 2017 / Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review / 생체재료학회지 21(2):17~36
Harada A / 1995 / Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments / Macromolecules 28:5294~5299
Yoon H / 2014 / Polymeric supramolecular assemblies based on multivalent ionic interactions for biomedical applications / Polymer 55:453~464
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