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논문 기본 정보

자료유형
학술저널
저자정보
Cha Jung Yoon (Department of Psychiatry Samsung Medical Center Sungkyunkwan University School of Medicine) Joung Yoo-Sook (Department of Psychiatry Samsung Medical Center Sungkyunkwan University School of Medicine) Oh Soohwan (Department of Psychiatry Samsung Medical Center Sungkyunkwan University School of Medicine) Kim Byung Wook (Department of Psychiatry Samsung Medical Center Sungkyunkwan University School of Medicine) Song In Mok (Department of Psychiatry Samsung Medical Center Sungkyunkwan University School of Medicine) Ahn Bo Mi (Department of Psychiatry Samsung Medical Center Sungkyunkwan University School of Medicine)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제18권 제9호
발행연도
2021.9
수록면
818 - 824 (7page)
DOI
10.30773/pi.2021.0047

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Objective This study aimed to determine the tic aggravation event rate and cumulative incidence rate in the use of methylphenidate (MPH) treatment in attention-deficit/hyperactivity disorder (ADHD) and the factors that influence tic aggravation.Methods We conducted a retrospective chart review of children and adolescents aged between 6 to 15 years, who were diagnosed with ADHD from January 2017 to December 2019. A total of 121 subjects were included. The MPH dosage, psychiatric family history, comorbidity and past history of tics were assessed through chart review and the psychological examinations data were included. Collected data were analyzed using Cox regression and Kaplan-Meier survival analysis.Results Tic aggravation event rates without a past history of tics were 2.9% with MPH treatment in ADHD. Past history of tics, total MPH dosage and age were the factors associated with tic aggravation ([HR 21.46, p<0.001], [HR 0.94, p=0.023], [HR 0.79, p=0.021] for each). Cumulative incidence of tic aggravation was different between groups with or without past tic history. When treated with MPH, all tic aggravation appeared within approximately eight months but for subjects with a past history of tic, aggravation showed within approximately six months (p<0.001).Conclusion Tic aggravation event rate was significantly low especially in the group without a past history of tics with the use of MPH in ADHD. However, a thorough assessment of past history of tics, and close monitoring during the first six-eight months of treatment with MPH is needed to avert a potential worsening of tics.
#Attention-deficit/hyperactivity disorder #Tic #Methylphenidate #Cumulative incidence.

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참고문헌 (31)

참고문헌 신청
Feldman HM / 2014 / Clinical practice. Attention deficit-hyperactivity disorder in children and adolescents / N Engl J Med 370:838~846 google schola Felt BT / 2014 / Diagnosis and management of ADHD in children / Am Fam Physician 90:456~464 google schola Floet AM / 2010 / Attention-deficit/hyperactivity disorder / Pediatr Rev 31:56~69 google schola Gabbard GO / 1995 / Treatments of Psychiatric Disorders / American Psychiatric Association google schola Spencer T / 1998 / Disentangling the overlap between Tourette’s disorder and ADHD / J Child Psychol Psychiatry 39:1037~1044 google schola

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