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논문 기본 정보

자료유형
학술저널
저자정보
Hee-Ju Kang (Chonnam National University) Ho-Yeon Lee (University of Science and Technology) Ki-Tae Kim (Korea University) Ju-Wan Kim (Chonnam National University) Ju-Yeon Lee (Chonnam National University) Sung-Wan Kim (Chonnam National University) Jung Chul Kim (Chonnam National University) Il-Seon Shin (Chonnam National University) Namshin Kim (University of Science and Technology) 김재민 (전남대학교병원)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제4호
발행연도
2021.11
수록면
683 - 694 (12page)
DOI
10.9758/cpn.2021.19.4.683

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초록· 키워드

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Objective: Sudden traumatic physical injuries often cause psychological distress, which may be associated with chronic disability. Although considerable effort has been expended to identify genetic predictors of post-traumatic stress disorder (PTSD) after traumatic events, genetic predictors of psychological distress in response to severe physical injuries have been yet to be elucidated using whole exome sequencing (WES). Here, the genetic architecture of post-traumatic syndrome (PTS), which encompasses a broad range of psychiatric disorders after traumatic events including depression, anxiety disorder, acute stress disorder, and PTSD, was explored using WES in severely physically injured patients, focusing on secondary findings and potential PTS-related variants. Methods: In total, 141 severely physically injured patients were consecutively recruited, and PTS was evaluated within 1 month of the injury. Secondary findings were analyzed according to PTS status. To identify PTS-related variants, genome-wide association analyses and the optimal sequencing kernel association test were performed. Results: Of the 141 patients, 88 (62%) experienced PTS. There were 108 disease-causing variants in severely physically injured patients. As secondary findings, the stress- and inflammation-related signaling pathways were enriched in the PTS patients, while the glucose metabolism pathway was enriched in those without PTS. However, no significant PTS-related variants were identified. Conclusion: Our findings suggest that genetic alterations in stress and inflammatory pathways might increase the likelihood of PTS immediately after severe physical injury. Future studies with larger samples and longitudinal designs are needed.
#Stress disorders #traumatic #Genetics #Whole exome sequencing #Incidental findings #Accidental injuries.

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참고문헌 (65)

참고문헌 신청
Schweininger S / 2015 / The temporal relationship between mental health and disability after injury / Depress Anxiety 32:64~71 google schola Kyungsoo Lee / 2019 / Posttraumatic Embitterment Disorder in Patients with Chronic Kidney Disease / Clinical Psychopharmacology and Neuroscience 17(2):183~188 dbpia Bryant RA / 2015 / Trajectory of post-traumatic stress following traumatic injury : 6-year follow-up / Br J Psychiatry 206:417~423 google schola Sharma S / 2019 / Genomic updates in understanding PTSD / Prog Neuropsychopharmacol Biol Psychiatry 90:197~203 google schola Yang S / 2018 / A clinician’s guide to PTSD biomarkers and their potential future use / Focus(Am Psychiatr Publ) 16:143~152 google schola

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