지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 69 - 81 (13page)
- DOI
- https://doi.org/10.5230/jgc.2018.18.e9
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초록· 키워드
오류제보하기
Purpose: It has been reported that the survival of patients with locally advanced gastric cancer (LAGC) is better in East Asia countries than in developed western countries; however, the prognosis of LAGC remains poor. This study aimed to evaluate the effects of perioperative chemotherapy on the long-term survival of East Asia patients with LAGC.
Materials and Methods: From October 2006 through August 2008, 43 patients with LAGC received perioperative S-1 combined with weekly docetaxel in a phase II study (neoadjuvant group). These patients were matched using propensity scores to patients who underwent surgery without neoadjuvant chemotherapy during the same period (surgery group). The surgical outcomes and long-term survivals were compared between the 2 groups.
Results: After matching, 43 and 86 patients were included in the neoadjuvant and surgery groups, respectively, and there was no significant difference in their baseline characteristics. Although the operating time was longer in the neoadjuvant group, there was no significant difference in postoperative complications between the 2 groups. The neoadjuvant group had a significantly higher 5-year overall survival (OS) rate (73.3% vs. 51.1%, P=0.005) and a trend towards higher 5-year progression-free survival (PFS) (62.8% vs. 49.9%, P=0.145). In the multivariate analysis, perioperative chemotherapy was an independent factor for OS, with a hazard ratio of 0.4 (P=0.005) and a marginal effect on the PFS (P=0.054).
Conclusions: Perioperative chemotherapy was associated with better long-term survival without increasing postoperative complications in the setting of D2 surgery for patients with LAGC, suggesting that perioperative chemotherapy can be a therapeutic option in East Asia countries.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Strong VE / 2010 / Comparison of gastric cancer survival following R0 resection in the United States and Korea using an internationally validated nomogram / Ann Surg 251:640~646
Oh Jeong / 2011 / Clinicopathological Features and Surgical Treatment of Gastric Cancer in South Korea: The Results of 2009 Nationwide Survey on Surgically Treated Gastric Cancer Patients / Journal of Gastric Cancer 11(2):69~77
Nashimoto A / 2013 / Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry / Gastric Cancer 16:1~27
Cunningham D / 2006 / Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer / N Engl J Med 355:11~20
Ychou M / 2011 / Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial / J Clin Oncol 29:1715~1721
Oh Jeong / 2011 / Clinicopathological Features and Surgical Treatment of Gastric Cancer in South Korea: The Results of 2009 Nationwide Survey on Surgically Treated Gastric Cancer Patients / Journal of Gastric Cancer 11(2):69~77
Nashimoto A / 2013 / Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry / Gastric Cancer 16:1~27
Cunningham D / 2006 / Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer / N Engl J Med 355:11~20
Ychou M / 2011 / Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial / J Clin Oncol 29:1715~1721
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