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논문 기본 정보

자료유형
학술저널
저자정보
Seung Joo Kang (Department of Internal Medicine Seoul National University Hospital Healthcare System Gangnam Center) Young Sin Cho (Division of Gastroenterology Cheonan Hospital Soonchunhyang University College of Medicine Cheonan) Tae Hee Lee (Institute for Digestive Research Digestive Disease Center Soonchunhyang University College of Medic) Seong-Eun Kim (Department of Internal Medicine College of Medicine Ewha Womans University Seoul Korea) Han Seung Ryu (Department of Internal Medicine Wonkwang University College of Medicine and Digestive Disease Resea) Jung-Wook Kim (Department of Internal Medicine Kyunghee University College of Medicine Seoul Korea) Seon-Young Park (Department of Internal Medicine Chonnam National University Medical School Gwangju Korea) Yoo Jin Lee (Department of Internal Medicine Keimyung University School of Medicine Daegu Korea) Jeong Eun Shin (Department of Internal Medicine Dankook University College of Medicine Cheonan Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.27 No.4
발행연도
2021.10
수록면
495 - 512 (18page)
DOI
10.5056/jnm20210

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Background/AimsConstipation is a common gastrointestinal problem in the elderly. Because of the limitations of life style modifications and the comorbidity, laxative use is also very common. Therefore, this study reviews the latest literature on the effect and safety of laxative in the elderly. MethodsA systematic review of randomized controlled trials investigating the effectiveness and safety of laxatives for constipation in elderly patients over 65 years old were performed using the following databases: PubMed, EMBASE, and the Cochrane Library. ResultsTwenty-three randomized controlled trials were included in this review. Among the selected studies, 9 studies compared laxative with placebo and 5 studies compared laxatives of the same type. Four studies compared different types of laxatives or compared combination agents. Five studies compared novel medications such as prucalopride, lubiprostone, and elobixibat with placebo. Psyllium, calcium polycarbophil, lactulose syrup, lactitol, polyethylene glycol, magnesium hydroxide, stimulant laxative with or without fiber, and other medications were more effective than placebo in elderly constipation patients in short-term. Generally, the frequency and severity of adverse effects of laxative were similar between the arms of studies. ConclusionsBulk laxative, osmotic laxative, stimulant laxative with or without fiber, and other medications can be used in elderly patients in short-term within 3 months with reasonable safety. However, the quality of included studies was not high and most of studies was conducted in a small number of patients. Among these laxatives, polyethylene glycol seems to be safe and effective in long-term use of about 6 months in elderly patients.
#Aged #Constipation #Laxatives #Systematic review

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참고문헌 (62)

참고문헌 신청
Higgins PD / 2004 / Epidemiology of constipation in North America : a systematic review / Am J Gastroenterol 99:750~759 google schola Talley NJ / 1992 / Prevalence of gastrointestinal symptoms in the elderly : a population-based study / Gastroenterology 102:895~901 google schola Wald A / 2008 / A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation / Aliment Pharmacol Ther 28:917~930 google schola Donald IP / 1985 / A study of constipation in the elderly living at home / Gerontology 31:112~118 google schola Akio Tamura / 2016 / Prevalence and Self-recognition of Chronic Constipation: Results of an Internet Survey / Journal of Neurogastroenterology and Motility (JNM) 22(4):677~685 dbpia

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