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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 335 - 340 (6page)
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초록· 키워드
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Although doxorubicin (Dox)-induced oxidative stress is known to be associated with cytotoxicity, the precise mechanism remains unclear. Genotoxic stress not only generates free radicals, but also affects actin cytoskeleton stability. We showed that Dox-induced RhoA signaling stimulated actin cytoskeleton alterations, resulting in central stress fiber disruption at early time points and cell periphery cortical actin formation at a later stage, in HeLa cells. Interestingly, activation of a cofilin phosphatase, chronophin (CIN), was initially evoked by Dox-induced RhoA signaling, resulting in a rapid phosphorylated cofilin turnover leading to actin cytoskeleton remodeling. In addition, a novel interaction between CIN and 14-3-3ζ was detected in the absence of Dox treatment. We demonstrated that CIN activity is quite contrary to 14-3-3ζ binding, and the interaction leads to enhanced phosphorylated cofilin levels. Therefore, initial CIN activation regulation could be critical in Dox-induced actin cytoskeleton remodeling through RhoA/cofilin signaling.
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참고문헌 (26)
참고문헌 신청
Pommier Y / 1985 / Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei / Biochemistry 24:6406~6410
Branzei D / 2008 / Regulation of DNA repair throughout the cell cycle / Nat Rev Mol Cell Biol 9:297~308
Croft DR / 2011 / p53- mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival / Cell Res 21:666~682
Ridley AJ / 2015 / Rho GTPase signalling in cell migration / Curr Opin Cell Biol 36:103~112
Spiering D / 2011 / Dynamics of the Rho-family small GTPases in actin regulation and motility / Cell Adh Migr 5:170~180
Branzei D / 2008 / Regulation of DNA repair throughout the cell cycle / Nat Rev Mol Cell Biol 9:297~308
Croft DR / 2011 / p53- mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival / Cell Res 21:666~682
Ridley AJ / 2015 / Rho GTPase signalling in cell migration / Curr Opin Cell Biol 36:103~112
Spiering D / 2011 / Dynamics of the Rho-family small GTPases in actin regulation and motility / Cell Adh Migr 5:170~180
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