지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국병원약사회 병원약사회지 병원약사회지 제38권 제4호
- 발행연도
- 2021.11
- 수록면
- 450 - 461 (12page)
- DOI
- 10.32429/jkshp.2021.38.4.003
이용수
초록· 키워드
오류제보하기
Background : Long-term parenteral nutrition (PN) can increase the risk of copper deficiency. This study aimed to analyze the incidence and risk factors associated with copper deficiency in infants requiring long-term PN and to evaluate the adequacy of intravenous (IV) copper supplementation.
Methods : This was a retrospective study of infants who were admitted to the neonatal intensive care unit (NICU) of a tertiary hospital in Korea from July of 2015 to June of 2020, had their serum copper concentration measured, and received PN for more than two weeks. Patients who were supplemented with IV copper and whose serum copper concentration was monitored after administration were placed in a subgroup to evaluate the copper supplementation.
Results : Of the 63 patients, 39 (61.9%) were deficient in copper (serum Cu <70 μg/dL). In the copper deficiency group, gestational age and birth weight were significantly lower, and the proportion of premature infants and extremely low-birth-weight infants were significantly higher. Gestational age of less than 32 weeks was an independent risk factor for copper deficiency.
In the copper deficiency group, the total NICU stay was longer, absolute neutrophil count, hemoglobin, and platelet levels were lower, and the proportion of bronchopulmonary dysplasia and rickets was higher.
Conclusion : Copper deficiency was common in infants receiving long-term PN without copper, especially in patients of young gestational age. Adequate copper supplements are recommended to prevent the clinical consequences of copper deficiency. It is necessary to develop single-entity products of IV copper or multi-trace element products suitable for infants.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Domellöf M / 2018 / ESPGHAN/ESPEN/ESPR/CSPEN working group on pediatric parenteral nutrition. ESPGHAN/ESPEN/ESPR/CS PEN guidelines on pediatric parenteral nutrition: Iron and trace minerals / Clin Nutr 37:2354~2359
Shike M / 2009 / Copper in parenteral nutrition / Gastroenterology 137(5 Suppl):S13~S17
Jin J / 2017 / Trace Elements in Parenteral Nutrition : Considerations for the Prescribing Clinician / Nutrients 9(5):440
Stehle P / 2016 / Parenteral trace element provision : recent clinical research and practical conclusions / Eur J Clin Nutr 70(8):886~893
Domellof M / 2014 / Nutritional care of premature infants : microminerals / World Rev Nutr Diet 110:121~139
Shike M / 2009 / Copper in parenteral nutrition / Gastroenterology 137(5 Suppl):S13~S17
Jin J / 2017 / Trace Elements in Parenteral Nutrition : Considerations for the Prescribing Clinician / Nutrients 9(5):440
Stehle P / 2016 / Parenteral trace element provision : recent clinical research and practical conclusions / Eur J Clin Nutr 70(8):886~893
Domellof M / 2014 / Nutritional care of premature infants : microminerals / World Rev Nutr Diet 110:121~139
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