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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 655 - 674 (20page)
- DOI
- 10.4093/dmj.2021.0197
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초록· 키워드
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Nonalcoholic fatty liver disease (NAFLD) is a major public health problem and the most common form of chronic liver disease, affecting 25% of the global population. Although NAFLD is closely linked with obesity, insulin resistance, and type 2 diabetes mellitus, knowledge on its pathogenesis remains incomplete. Emerging data have underscored the importance of Rho-kinase (Rho-associated coiled-coil-containing kinase [ROCK]) action in the maintenance of normal hepatic lipid homeostasis. In particular, pharmacological blockade of ROCK in hepatocytes or hepatic stellate cells prevents the progression of liver diseases such as NAFLD and fibrosis. Moreover, mice lacking hepatic ROCK1 are protected against obesity-induced fatty liver diseases by suppressing hepatic de novo lipogenesis. Here we review the roles of ROCK as an indispensable regulator of obesity-induced fatty liver disease and highlight the key cellular pathway governing hepatic lipid accumulation, with focus on de novo lipogenesis and its impact on therapeutic potential. Consequently, a comprehensive understanding of the metabolic milieu linking to liver dysfunction triggered by ROCK activation may help identify new targets for treating fatty liver diseases such as NAFLD.
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참고문헌 (138)
참고문헌 신청
Birkenfeld AL / 2014 / Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes / Hepatology 59:713~723
Kopelman PG / 2000 / Obesity as a medical problem / Nature 404:635~643
Ronan Thibaut / 2021 / Liver macrophages and inflammation in physiology and physiopathology of non‐alcoholic fatty liver disease / The FEBS Journal
Ayonrinde OT / 2021 / Historical narrative from fatty liver in the nineteenth century to contemporary NAFLD : reconciling the present with the past / JHEP Rep 3:100261
Wong RJ / 2015 / Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States / Gastroenterology 148:547~555
Kopelman PG / 2000 / Obesity as a medical problem / Nature 404:635~643
Ronan Thibaut / 2021 / Liver macrophages and inflammation in physiology and physiopathology of non‐alcoholic fatty liver disease / The FEBS Journal
Ayonrinde OT / 2021 / Historical narrative from fatty liver in the nineteenth century to contemporary NAFLD : reconciling the present with the past / JHEP Rep 3:100261
Wong RJ / 2015 / Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States / Gastroenterology 148:547~555
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