지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제18권 제4호
- 발행연도
- 2017.12
- 수록면
- 130 - 135 (6page)
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초록· 키워드
오류제보하기
Adhesive capsulitis of the shoulder is a common cause of pain that occurs during shoulder movement, thereby restricting shoulder rotation in clinical practice. Although most patients respond to pain relief treatment (NSAID or corticosteroids) by improving their range of motion, it remains poorly understood without any definitive treatment algorithm. In addition to immune cells, synoviocytes, chondrocytes and osteoblasts in the joint are known to produce pro-inflammatory mediators such as reactive oxygen species (ROS), inflammatory cytokines and lipid mediators, presumably contributing to the pathogenesis of osteoarthritis (OA) and adhesive capsulitis. Although inflammation and also fibrosis are proposed to be the basic pathological changes of a frozen shoulder, there is a lack of information regarding the downstream targets of the pro-inflammatory ROS signaling pathway in the synoviocytes and also how these ROS targets are modulated at the transcription level by a corticosteroid - dexamethasone. In this study, we used human fibroblast like synoviocytes (HFLS) to characterize the signaling targets of ROS by employing a human DNA microarray tool and studied the role of dexamethasone in this process. Our data suggest that several genes such as FOS, FOSB and NFkBIZ, which are known to be involved in pro- or anti- inflammation response, are modulated at the transcription level by ROS and dexamethasone.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Tamai K / 2014 / Primary frozen shoulder : brief review of pathology and imaging abnormalities / J Orthop Sci 19:1~5
Cui J / 2017 / Molecular biology of frozen shoulder-induced limitation of shoulder joint movements / J Res Med Sci 22:61
Lepetsos P / 2016 / ROS/oxidative stress signaling in osteoarthritis / Biochim Biophys Acta 1862:576~591
Richter K / 2015 / Redox-fibrosis: Impact of TGFbeta1 on ROS generators, mediators and functional consequences / Redox Biol 6:344~352
Bunker TD / 1995 / Frozen shoulder and lipids / J Bone Joint Surg Br 77:684~686
Cui J / 2017 / Molecular biology of frozen shoulder-induced limitation of shoulder joint movements / J Res Med Sci 22:61
Lepetsos P / 2016 / ROS/oxidative stress signaling in osteoarthritis / Biochim Biophys Acta 1862:576~591
Richter K / 2015 / Redox-fibrosis: Impact of TGFbeta1 on ROS generators, mediators and functional consequences / Redox Biol 6:344~352
Bunker TD / 1995 / Frozen shoulder and lipids / J Bone Joint Surg Br 77:684~686
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