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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 153 - 160 (8page)
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초록· 키워드
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Tyrosine kinase inhibitors (TKIs) are targeted therapy drugs that selectively inhibit protein kinases. Nephrotoxicity associated with TKIs is uncommon. We report a case of a 39-year-old man with acute kidney injury that developed after nilotinib treatment for chronic myeloid leukemia (CML). The renal function of the patient decreased during treatment with nilotinib but improved when treatment was discontinued due to neutropenia. However, the renal function of the patient deteriorated again with the reintroduction of nilotinib for treatment. A renal biopsy revealed acute interstitial nephritis (AIN). The patient had no history of comorbidities and medication causing renal injury. Finally, we diagnosed the patient with nilotinib-induced AIN. After switching to imatinib mesylate, the renal function of the patient stabilized without further deterioration. Our case indicates that nilotinib can be a potential cause of renal dysfunction by inducing AIN when renal function deteriorates in patients treated with nilotinib.
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Jabbour E / 2015 / Use of Second-and Third-Generation Tyrosine Kinase Inhibitors in the Treatment of Chronic Myeloid Leukemia : An Evolving Treatment Paradigm / Clinical Lymphoma Myeloma and Leukemia 15:323~324
Blay JY / 2011 / Nilotinib: a novel, selective tyrosine kinase inhibitor / Semin Oncol 38(Suppl 1):S3~9
Jhaveri KD / 2016 / Adverse Renal Effects of Novel Molecular Oncologic Targeted Therapies : A Narrative Review / Kidney Int Rep 2:108~123
Yilmaz M / 2015 / Estimated glomerular filtration rate changes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors / Cancer 121:3894~3904
Ren X / 2019 / Assessment of chronic renal injury in patients with chronic myeloid leukemia in the chronic phase receiving tyrosine kinase inhibitors / Ann Hematol 98:1627~1640
Blay JY / 2011 / Nilotinib: a novel, selective tyrosine kinase inhibitor / Semin Oncol 38(Suppl 1):S3~9
Jhaveri KD / 2016 / Adverse Renal Effects of Novel Molecular Oncologic Targeted Therapies : A Narrative Review / Kidney Int Rep 2:108~123
Yilmaz M / 2015 / Estimated glomerular filtration rate changes in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors / Cancer 121:3894~3904
Ren X / 2019 / Assessment of chronic renal injury in patients with chronic myeloid leukemia in the chronic phase receiving tyrosine kinase inhibitors / Ann Hematol 98:1627~1640
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