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논문 기본 정보

자료유형
학술저널
저자정보
Iffat Khanum (Aga Khan University) Lokesh Kumar (Aga Khan University) Safia Awan (Aga Khan University) Bushra Jamil (Aga Khan University)
저널정보
대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.10 No.3
발행연도
2021.9
수록면
276 - 281 (6page)

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Purpose: Considering the cross-protection reported for bacillus Calmette-Guerin (BCG) vaccination on viral respiratory infections, it has been proposed that it could reduce the severity of coronavirus disease 2019 (COVID-19). The objective of the current study is to investigate the association between the severity of COVID-19 with prior BCG vaccination in adult patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Materials and Methods: Adult patients (18 years or above) with positive SARS-CoV-2 polymerase chain reaction admitted in July 2020 were included in this cross-sectional study. Patients were classified into non-severe, severe, and critical diseases. History of prior BCG vaccination and the presence of a BCG vaccination scar were recorded. Results: Out of 103 patients, 64 patients with prior history of BCG vaccinations were compared with 39 patients without BCG vaccination in childhood. The median age was 55 years and 64 years in BCG vaccinated & non-BCG vaccinated patients (p-value=0.002). There was male predominance in both groups and frequent comorbid illnesses were hypertension and diabetes mellitus. Severe COVID-19 was found in 91 patients (88.3%) followed by non-severe disease and critical diseases i.e., 7 (6.8%) and 5 (4.9%) patients, respectively. No association of prior BCG vaccination with disease severity of COVID-19 was found in this study and mortality was 8.7%. Out of nine patients who expired only 2 (22.2%) had a prior history of BCG vaccination (p-value=0.01). Secondary infections were present in 26 patients and the majority had pneumonia. Conclusion: The BCG vaccine has no impact on the severity of COVID-19 but could have a protective role with a low mortality rate in already infected patients.
#COVID-19 #BCG vaccine #SARS-CoV-2

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참고문헌 (31)

참고문헌 신청
Colditz GA / 1995 / The efficacy of bacillus Calmette-Guerin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature / Pediatrics 96(1 Pt 1):29~35 google schola Trunz BB / 2006 / Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide : a meta-analysis and assessment of cost-effectiveness / Lancet 367:1173~1180 google schola Cernuschi T / 2018 / Bacillus Calmette-Guerin(BCG)vaccine : a global assessment of demand and supply balance / Vaccine 36:498~506 google schola Stensballe LG / 2005 / Acute lower respiratory tract infections and respiratory syncytial virus in infants in Guinea-Bissau : a beneficial effect of BCG vaccination for girls community based case-control study / Vaccine 23:1251~1257 google schola Wardhana / 2011 / The efficacy of bacillus Calmette-Guerin vaccinations for the prevention of acute upper respiratory tract infection in the elderly / Acta Med Indones 43:185~190 google schola

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