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논문 기본 정보

자료유형
학술저널
저자정보
Lee You-Bin (Division of Endocrinology and Metabolism Department of Medicine Samsung Medical Center Sungkyunkwan) Kim Bongsung (Department of Statistics and Actuarial Science Soongsil University Seoul Korea.) Han Kyungdo (Department of Statistics and Actuarial Science Soongsil University Seoul Korea.) Kim Jung A (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University Guro Hosp) Roh Eun (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University Guro Hosp) Hong So-hyeon (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University Guro Hosp) Choi Kyung Mook (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University Guro Hosp) Baik Sei Hyun (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University Guro Hosp) Yoo Hye Jin (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University Guro Hosp)
저널정보
한국지질동맥경화학회(구 한국지질학회) 지질·동맥경화학회지 지질·동맥경화학회지 제10권 제3호
발행연도
2021.9
수록면
303 - 312 (10page)
DOI
10.12997/jla.2021.10.3.303

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초록· 키워드

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Objective: We investigated the effects of statin-ezetimibe combination therapy compared with statin-only treatment on the hazard of incident type 2 diabetes (T2D), myocardial infarction (MI), and stroke among adults with impaired fasting glucose (IFG) in a real-world setting. Methods: The Korean National Health Insurance Service datasets from 2002 to 2017 were used for this propensity-matched nationwide cohort study. Among 56,633 IFG patients without baseline cardiovascular disease (CVD) and/or T2D who initiated statin therapy with or without ezetimibe, 1,155 with statin-ezetimibe combination therapy were matched based on a propensity score at a 1:5 ratio with 5,775 patients who received statin monotherapy. The hazards of T2D, MI, and stroke were compared between these treatment groups. Results: The incidence rate per 1,000 person-years was 19.62 (statin monotherapy group) and 21.02 (combined treatment group) for T2D, 1.53 (statin monotherapy group) and 1.70 (combined treatment group) for MI, and 1.99 (statin monotherapy group) and 2.06 (combined treatment group) for stroke. The hazards of T2D, MI, and stroke were not significantly different between the statin monotherapy group and the statin-ezetimibe combination therapy group. Conclusion: The combination of ezetimibe in addition to statin treatment was not associated with a significantly different risk of T2D and CVDs compared with statin monotherapy in Korean adults with IFG.
#Statin #Ezetimibe #Prediabetic state #Type 2 diabetes #Cardiovascular diseases

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참고문헌 (30)

참고문헌 신청
Ridker PM / 2012 / Cardiovascular benefits and diabetes risks of statin therapy in primary prevention : an analysis from the JUPITER trial / Lancet 380:565~571 google schola Rajpathak SN / 2012 / Intensive statin therapy, compared with moderate dose, increases risk of new onset diabetes but decreases risk of cardiovascular events / Evid Based Med 17:55~56 google schola Sattar N / 2010 / Statins and risk of incident diabetes : a collaborative meta-analysis of randomised statin trials / Lancet 375:735~742 google schola Zafrir B / 2014 / Lipid-lowering therapies, glucose control and incident diabetes : evidence, mechanisms and clinical implications / Cardiovasc Drugs Ther 28:361~377 google schola Barkas F / 2016 / Statin therapy with or without ezetimibe and the progression to diabetes / J Clin Lipidol 10:306~313 google schola

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