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논문 기본 정보

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학술저널
저자정보
Manabe Osamu (Department of Nuclear Medicine Hokkaido University Graduate School of Medicine Sapporo Japan.) Oyama-Manabe Noriko (Department of Diagnostic and Interventional Radiology Hokkaido University Hospital Sapporo Japan.) Naya Masanao (Department of Cardiovascular Medicine Hokkaido University Graduate School of Medicine Sapporo Japan) Obara Masahiko (Department of Cardiovascular Medicine Hokkaido University Graduate School of Medicine Sapporo Japan) Kikuchi Yasuka (Center for Cause of Death Investigation Faculty of Medicine Hokkaido University Sapporo Japan.) Aikawa Tadao (Department of Cardiovascular Medicine Hokkaido University Graduate School of Medicine Sapporo Japan) Tomiyama Yuuki (Department of Nuclear Medicine Hokkaido University Graduate School of Medicine Sapporo Japan.) Sugimori Hiroyuki (Department of Diagnostic and Interventional Radiology Hokkaido University Hospital Sapporo Japan.) Katoh Chietsugu (Faculty of Health Sciences Hokkaido University Graduate School of Health Sciences Sapporo Japan.) Tamaki Nagara (Department of Radiology Kyoto Prefectural University of Medicine Kyoto Japan.) Anzai Toshihisa (Department of Cardiovascular Medicine Hokkaido University Graduate School of Medicine Sapporo Japan)
저널정보
아시아심장혈관영상의학회 Cardiovascular Imaging Asia Cardiovascular Imaging Asia Vol.3 No.1
발행연도
2019.1
수록면
8 - 14 (7page)
DOI
10.22468/cvia.2018.00227

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Objective: Although the relationship between coronary stenosis and myocardial perfusion is well established, little is known regarding the contribution of subendocardial infarction to this relationship. The purpose of this study was to evaluate the effects of obstructive coronary stenosis and subendocardial infarction on myocardial flow reserve (MFR). Materials and Methods: Fifty-four patients with suspected and known coronary artery disease (CAD) who underwent perfusion 3T-MRI and invasive angiography were studied. The time-intensity curves of the left ventricle tissue and cavity were fitted by a single-compartment model to compute myocardial blood flow (MBF). Global MFR and regional MFR were calculated by dividing stress MBF by rest MBF. Myocardial infarction lesions were assessed by late gadolinium enhancement. The effects of obstructive coronary stenosis and subendocardial infarction on the regional MFR were evaluated. Results: Obstructed vessels (≥70% diameter stenosis for main vessels or ≥50% for left main) were observed in 65 out of 162 vessels. Further analysis demonstrated that MFR in obstructed vessels was significantly lower than that in non-obstructed vessels {1.48 [the interquartile range (IQR) : 1.31?2.03] vs. 1.84 (IQR: 1.44?2.46), p=0.01}. After excluding vessels with transmural infarction (n=19), the MFR for vessels with subendocardial infarction (n=20) was significantly lower than the MFR for non-infarction vessels (n=123) [1.48 (IQR: 1.40?1.79) vs. 1.88 (IQR: 1.41?2.48), p=0.02]. Conclusion: Subendocardial infarction in addition to obstructive coronary atherosclerosis might be associated with an impairment of regional MFR in patients with CAD.
#Myocardial perfusion imaging # Flow reserve #Magnetic resonance imaging #Perfusion #Coronary artery disease

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