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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Retromer is an important endosomal trafficking protein assembly that takes part in transporting the membrane cargo.
Endosomal trafficking involves sorting of proteins from the endosome and transporting them through different pathways inthe cell. The three major pathways of endosomal trafficking are recycling, retrograde, and degradation pathways; retromersare involved in the first two types of pathways. Since 2005, many researches have studied the correlation betweenretromer and different neurodegenerative diseases. Since the first study on Alzheimer's, numerous studies on otherneurodegenerative diseases, including Parkinson’s disease and Neuronal Ceroid Lipofuscinosis, revealed that dysfunctionof the retromer contributes to these afflictions. It is therefore important to understand the molecular mechanism behindthe process. Recent studies have shown the potential of retromer as a drug target. Therapeutic agents, such as retromerchaperone, have been found to improve the function of retromer without affecting other pathways.
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참고문헌 (31)
참고문헌 신청
Arighi, C. N / 2004 / Role of the mammalian retromer in sorting of the cationindependent mannose 6-phosphate receptor / J Cell Biol 165:123~133
Attar, N / 2010 / The retromer complex / Adv Enzyme Regul 50:216~236
Carlton, J / 2004 / Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-phosphoinositides / Current Biology 14:1791~1800
Cozier, G. E / 2002 / The Phox Homology(PX)domaindependent, 3-phosphoinositide-mediated association of sorting nexin-1with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation / Journal of Biological Chemistry 277:48730~48736
Cullen, P. J / 2011 / Sorting nexins provide diversity for retromer-dependent trafficking events / Nat Cell Biol 14:29~37
Attar, N / 2010 / The retromer complex / Adv Enzyme Regul 50:216~236
Carlton, J / 2004 / Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-phosphoinositides / Current Biology 14:1791~1800
Cozier, G. E / 2002 / The Phox Homology(PX)domaindependent, 3-phosphoinositide-mediated association of sorting nexin-1with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation / Journal of Biological Chemistry 277:48730~48736
Cullen, P. J / 2011 / Sorting nexins provide diversity for retromer-dependent trafficking events / Nat Cell Biol 14:29~37
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