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논문 기본 정보

자료유형
학술저널
저자정보
송신정 (연세대학교) 양필성 (연세대학교) 김태훈 (연세대학교) 엄재선 (연세대학교) 박희남 (연세대학교) 이문형 (연세대학교) 정보영 (연세대학교)
저널정보
대한부정맥학회 International Journal of Arrhythmia International Journal of Arrhythmia 제18권 제4호
발행연도
2017.12
수록면
176 - 184 (9page)
DOI
https://doi.org/10.18501/arrhythmia.2017.028

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Background: Although a few previous studies have analyzed the role of reduced lung function in predicting atrial fibrillation (AF), the relationship between the incidence of AF and comorbid chronic obstructive pulmonary disease (COPD) is unclear. We hypothesized that COPD is associated with the occurrence of new-onset AF and clinical outcomes in AF patients. Methods: We analyzed the development of new-onset AF in 501,668 patients without AF and clinical outcomes in 4,541 patients with AF using Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC). Results: Comorbid COPD was found in 4.8% (11,442 of 501,668) of non-AF patients and 18.6% (820 of 4,541) of AF patients. The incidence of AF in COPD patients was significantly higher compared to non-COPD patients (2.6% vs. 0.6%, p<0.001) over the follow-up period (45.5±14.9 months). In a multivariate Cox regression analysis, COPD predicted higher risk of AF independently from other risk factors (HR: 1.41, 95% CI: 1.25-1.60, p<0.001). The all-cause mortality of AF patients with COPD was significantly higher in patients who used b-blockers (20.6% vs 13.1% during follow-up, p<0.008). Multivariate Cox regression analysis showed that COPD is still an independent risk factor for all-cause mortality (HR: 1.25, 95% CI: 1.03-1.51, p=0.022), and stroke (HR: 1.19, 95% CI: 1.00- 1.41, p=0.039). Conclusion: The presence of COPD is an independent risk factor for new-onset AF. COPD is independently associated with all-cause mortality and stroke in AF patients.

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