지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 161 - 169 (9page)
- DOI
- 10.25289/ML.2021.10.3.161
이용수
초록· 키워드
오류제보하기
Background and Objectives Fractional microneedle radiofrequency systems are popular options to increase elasticity in aging skin. Laser-assisted drug delivery is a promising method for the epidermal injection of topically applied drugs and cosmetic ingredients. This study assesses the safety and efficacy of topical delivery of L-ascorbic acid, vitamin E, and ferulic acid after fractional microneedle radiofrequency treatment for reducing photodamage.
Materials and Methods In this prospective, single-center, split-face, controlled pilot study, six women (mean age, 48.0 years; range, 35-57 years; Fitzpatrick skin types III and IV) exhibiting mild to moderate photodamage, underwent a single session of fractional microneedle radiofrequency treatment. The patients were instructed to apply the antioxidant formulation to only one side of the face. Patients were evaluated 3 days, 7 days, and 4 weeks thereafter, using three-dimensional imaging and ultrasound. Ex vivo , the fullthickness human skin was used for molecular and histological evaluation. Statistical analysis was achieved by applying t-tests, Mann- Whitney U tests, and one-way analyses of variance.
Results Compared to the untreated side, the antioxidant-treated side exhibited a significant increase in dermal thickness (10.32% vs. 17.54%, p < 0.05), but not in skin elasticity (4.76% vs. 4.69%, p > 0.05). The difference in erythema between the sides was statistically not significant (p > 0.05). In the ex vivo model, expression of FGF2 in the skin was significantly increased after application of the antioxidant formulation, as compared to results obtained subsequent to fractional microneedle radiofrequency treatment only (p < 0.01).
Conclusion This study demonstrates that for the treatment of photodamaged skin, laser-assisted delivery of the antioxidant formulation is a safe and effective adjuvant modality following fractional microneedle radiofrequency.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Nkengne A / 2013 / Aging and facial changes--documenting clinical signs, part 1 : clinical changes of the aging face / Skinmed 11:281~286
Britt CJ / 2017 / Energy-based facial rejuvenation : advances in diagnosis and treatment / JAMA Facial Plast Surg 19:64~71
Gold MH / 2017 / The future of non-invasive rejuvenation technology : devices / J Drugs Dermatol 16:s104~s107
Hantash BM / 2009 / Bipolar fractional radiofrequency treatment induces neoelastogenesis and neocollagenesis / Lasers Surg Med 41:1~9
Manuskiatti W / 2016 / Thermal response of in vivo human skin to fractional radiofrequency microneedle device / Biomed Res Int 2016:6939018
Britt CJ / 2017 / Energy-based facial rejuvenation : advances in diagnosis and treatment / JAMA Facial Plast Surg 19:64~71
Gold MH / 2017 / The future of non-invasive rejuvenation technology : devices / J Drugs Dermatol 16:s104~s107
Hantash BM / 2009 / Bipolar fractional radiofrequency treatment induces neoelastogenesis and neocollagenesis / Lasers Surg Med 41:1~9
Manuskiatti W / 2016 / Thermal response of in vivo human skin to fractional radiofrequency microneedle device / Biomed Res Int 2016:6939018
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