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자료유형
학술저널
저자정보
Ulep Tiffany-Heather (The University of Arizona) Yoon Jeong-Yeol (The University of Arizona)
저널정보
나노기술연구협의회 Nano Convergence Nano Convergence Vol.5 No.14
발행연도
2018.5
수록면
1 - 11 (11page)
DOI
10.1186/s40580-018-0146-1

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초록· 키워드

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Application of optically superior, tunable fluorescent nanotechnologies have long been demonstrated throughout many chemical and biological sensing applications. Combined with microfluidics technologies, i.e. on lab-on-a-chip platforms, such fluorescent nanotechnologies have often enabled extreme sensitivity, sometimes down to single molecule level. Within recent years there has been a peak interest in translating fluorescent nanotechnology onto paper-based platforms for chemical and biological sensing, as a simple, low-cost, disposable alternative to conventional silicone-based microfluidic substrates. On the other hand, smartphone integration as an optical detection system as well as user interface and data processing component has been widely attempted, serving as a gateway to on-board quantitative processing, enhanced mobility, and interconnectivity with informational networks. Smartphone sensing can be integrated to these paper-based fluorogenic assays towards demonstrating extreme sensitivity as well as ease-of-use and low-cost. However, with these emerging technologies there are always technical limitations that must be addressed; for example, paper’s autofluorescence that perturbs fluorogenic sensing; smartphone flash’s limitations in fluorescent excitation; smartphone camera’s limitations in detecting narrow-band fluorescent emission, etc. In this review, physical optical setups, digital enhancement algorithms, and various fluorescent measurement techniques are discussed and pinpointed as areas of opportunities to further improve paper-based fluorogenic optical sensing with smartphones.

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