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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Ischemic stroke is a leading cause of death and disability. Tissue plasminogen activator is the only U.S. Food and Drug Administration approved thrombolytic therapy for ischemic stroke patients till date. However, its use is limited due to increased risk of bleeding and narrow therapeutic window.
Most of the preclinically tested pharmacological agents failed to be translated to the clinic. This drives the need for alternative therapeutic approaches that not only provide enhanced neuroprotection, but also reduce the risk of stroke. Physical exercise is a sort of preconditioning that provides the body with brief ischemic episodes that can protect the body from subsequent severe ischemic attacks like stroke. Physical exercise is known to improve cardiovascular health.
However, its role in providing neuroprotection in stroke is not clear. Clinical observational studies showed a correlation between regular physical exercise and reduced risk and severity of ischemic stroke and better outcomes after stroke. However, the underlying mechanisms through which prestroke exercise can reduce the stroke injury and improve the outcomes are not completely understood. The purpose of this review is to: demonstrate the impact of exercise on stroke outcomes and show the potential role of exercise in stroke prevention and recovery; uncover the underlying mechanisms through which exercise reduces the neurovascular injury and improves stroke outcomes aiming to develop novel therapeutic approaches.
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등록된 정보가 없습니다.
참고문헌 (92)
참고문헌 신청
Powers WJ / 2019 / Guidelines for the early management of patients with acute ischemic stroke : 2019 update to the 2018 guidelines for the early management of acute ischemic stroke : a guideline for healthcare professionals from the American Heart Association/American Stroke Association / Stroke 50:e344~e418
Powers WJ / 2018 / 2018 Guidelines for the early management of patients with acute ischemic stroke : a guideline for healthcare professionals from the American Heart Association/American Stroke Association / Stroke 49:e46~e110
Przyklenk K / 2011 / Remote ischemic preconditioning:current knowledge, unresolved questions, and future priorities / J Cardiovasc Pharmacol Ther 16:255~259
Hess DC / 2015 / Remote ischaemic conditioning-a new paradigm of self-protection in the brain / Nat Rev Neurol 11:698~710
Thijssen DHJ / 2018 / Association of exercise preconditioning with immediate cardioprotection : a review / JAMA Cardiol 3:169~176
Powers WJ / 2018 / 2018 Guidelines for the early management of patients with acute ischemic stroke : a guideline for healthcare professionals from the American Heart Association/American Stroke Association / Stroke 49:e46~e110
Przyklenk K / 2011 / Remote ischemic preconditioning:current knowledge, unresolved questions, and future priorities / J Cardiovasc Pharmacol Ther 16:255~259
Hess DC / 2015 / Remote ischaemic conditioning-a new paradigm of self-protection in the brain / Nat Rev Neurol 11:698~710
Thijssen DHJ / 2018 / Association of exercise preconditioning with immediate cardioprotection : a review / JAMA Cardiol 3:169~176
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